TY - JOUR
T1 - Early childhood appetitive traits and eating disorder symptoms in adolescence
T2 - a 10-year longitudinal follow-up study in the Netherlands and the UK
AU - Derks, Ivonne P.M.
AU - Nas, Zeynep
AU - Harris, Holly A.
AU - Kininmonth, Alice R.
AU - Treasure, Janet
AU - Jansen, Pauline W.
AU - Llewellyn, Clare H.
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Elsevier Ltd.
PY - 2024/4
Y1 - 2024/4
N2 - Background: Obesity and eating disorders commonly co-occur and might share common risk factors. Appetite avidity is an established neurobehavioural risk factor for obesity from early life, but the role of appetite in eating disorder susceptibility is unclear. We aimed to examine longitudinal associations between appetitive traits in early childhood and eating disorder symptoms in adolescence. Methods: In this longitudinal cohort study, we used data from Generation R (based in Rotterdam, the Netherlands) and Gemini (based in England and Wales). Appetitive traits at age 4–5 years were measured using the parent-reported Child Eating Behaviour Questionnaire. At age 12–14 years, adolescents self-reported on overeating eating disorder symptoms (binge eating symptoms, uncontrolled eating, and emotional eating) and restrictive eating disorder symptoms (compensatory behaviours and restrained eating). Missing data on covariates were imputed using Multivariate Imputation via Chained Equations. Ordinal and binary logistic regressions were performed in each cohort separately and adjusted for confounders. Pooled results were obtained by meta-analyses. Sensitivity analyses were performed on complete cases using inverse probability weighting. Findings: The final study sample included 2801 participants from Generation R and 869 participants from Gemini. Pooled findings after meta-analyses showed that higher food responsiveness in early childhood increased the odds of binge eating symptoms (odds ratio [OR]pooled 1·47, 95% CI 1·26–1·72), uncontrolled eating (1·33, 1·21–1·46), emotional eating (1·26, 1·13–1·41), restrained eating (1·16, 1·06–1·27), and compensatory behaviours (1·18, 1·08–1·30) in adolescence. Greater emotional overeating in early childhood increased the odds of compensatory behaviours (1·18, 1·06–1·33). By contrast, greater satiety responsiveness in early childhood decreased the odds of compensatory behaviours in adolescence (0·89, 0·81–0·99) and uncontrolled eating (0·86, 0·78–0·95) in adolescence. Slower eating in early childhood decreased the odds of compensatory behaviours (0·91, 0·84–0·99) and restrained eating (0·90, 0·83–0·98) in adolescence. No other associations were observed. Interpretation: In this study, higher food responsiveness in early childhood was associated with a higher likelihood of self-reported eating disorder symptoms in adolescence, whereas greater satiety sensitivity and slower eating were associated with a lower likelihood of some eating disorder symptoms. Appetitive traits in children might be early neurobehavioural risk factors for, or markers of, subsequent eating disorder symptoms. Funding: MQ Mental Health Research, Rosetrees Trust, ZonMw.
AB - Background: Obesity and eating disorders commonly co-occur and might share common risk factors. Appetite avidity is an established neurobehavioural risk factor for obesity from early life, but the role of appetite in eating disorder susceptibility is unclear. We aimed to examine longitudinal associations between appetitive traits in early childhood and eating disorder symptoms in adolescence. Methods: In this longitudinal cohort study, we used data from Generation R (based in Rotterdam, the Netherlands) and Gemini (based in England and Wales). Appetitive traits at age 4–5 years were measured using the parent-reported Child Eating Behaviour Questionnaire. At age 12–14 years, adolescents self-reported on overeating eating disorder symptoms (binge eating symptoms, uncontrolled eating, and emotional eating) and restrictive eating disorder symptoms (compensatory behaviours and restrained eating). Missing data on covariates were imputed using Multivariate Imputation via Chained Equations. Ordinal and binary logistic regressions were performed in each cohort separately and adjusted for confounders. Pooled results were obtained by meta-analyses. Sensitivity analyses were performed on complete cases using inverse probability weighting. Findings: The final study sample included 2801 participants from Generation R and 869 participants from Gemini. Pooled findings after meta-analyses showed that higher food responsiveness in early childhood increased the odds of binge eating symptoms (odds ratio [OR]pooled 1·47, 95% CI 1·26–1·72), uncontrolled eating (1·33, 1·21–1·46), emotional eating (1·26, 1·13–1·41), restrained eating (1·16, 1·06–1·27), and compensatory behaviours (1·18, 1·08–1·30) in adolescence. Greater emotional overeating in early childhood increased the odds of compensatory behaviours (1·18, 1·06–1·33). By contrast, greater satiety responsiveness in early childhood decreased the odds of compensatory behaviours in adolescence (0·89, 0·81–0·99) and uncontrolled eating (0·86, 0·78–0·95) in adolescence. Slower eating in early childhood decreased the odds of compensatory behaviours (0·91, 0·84–0·99) and restrained eating (0·90, 0·83–0·98) in adolescence. No other associations were observed. Interpretation: In this study, higher food responsiveness in early childhood was associated with a higher likelihood of self-reported eating disorder symptoms in adolescence, whereas greater satiety sensitivity and slower eating were associated with a lower likelihood of some eating disorder symptoms. Appetitive traits in children might be early neurobehavioural risk factors for, or markers of, subsequent eating disorder symptoms. Funding: MQ Mental Health Research, Rosetrees Trust, ZonMw.
UR - http://www.scopus.com/inward/record.url?scp=85185571252&partnerID=8YFLogxK
U2 - 10.1016/S2352-4642(23)00342-5
DO - 10.1016/S2352-4642(23)00342-5
M3 - Article
C2 - 38395044
AN - SCOPUS:85185571252
SN - 2352-4642
VL - 8
SP - 270
EP - 279
JO - The Lancet Child and Adolescent Health
JF - The Lancet Child and Adolescent Health
IS - 4
ER -