TY - JOUR
T1 - Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network
T2 - individual participant data meta-analysis of over 109,000 individuals
AU - Gonçalves, Romy
AU - Blaauwendraad, Sophia
AU - Avraam, Demetris
AU - Beneíto, Andrea
AU - Charles, Marie Aline
AU - Elhakeem, Ahmed
AU - Escribano, Joaquin
AU - Etienne, Louise
AU - García-Baquero Moneo, Gonzalo
AU - Soares, Ana Gonçalves
AU - de Groot, Jasmin
AU - Grote, Veit
AU - Gruszfeld, Dariusz
AU - Guerlich, Kathrin
AU - Guxens, Monica
AU - Heude, Barbara
AU - Koletzko, Berthold
AU - Lertxundi, Aitana
AU - Lozano, Manuel
AU - El Marroun, Hanan
AU - McEachan, Rosie
AU - Pinot de Moira, Angela
AU - Santorelli, Gillian
AU - Strandberg-Larsen, Katrine
AU - Tafflet, Muriel
AU - Vainqueur, Chloe
AU - Verduci, Elvira
AU - Vrijheid, Martine
AU - Welten, Marieke
AU - Wright, John
AU - Yang, Tiffany C.
AU - Gaillard, Romy
AU - Jaddoe, Vincent W.V.
N1 - Publisher Copyright: © 2025 The Author(s)
PY - 2025/5
Y1 - 2025/5
N2 - Background: Fetal and infant development might be critical for cognitive outcomes and psychopathology later in life. We assessed the associations of birth characteristics and early life growth with behavior and cognitive outcomes from childhood to adolescence. Methods: We used harmonized data of 109,481 children from 8 European birth cohorts. Birth weight, gestational age, and body mass index (BMI) tertiles at the age of 2 years were used as the exposure variables. Outcomes included internalizing and externalizing problems and attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and non-verbal intelligence quotient (Non-verbal IQ) in childhood (4–10 years), early adolescence (11–16 years), and late adolescence (17–20 years). We used 1-stage individual participant data meta-analyses using generalized linear models. Findings: A one-week older gestational age was associated with lower scores for internalizing problems (difference −0·48 (95% CI: −0·59, −0·37)), externalizing problems (difference −0·34 (95% CI: −0·44, −0·23)), and ADHD symptoms (difference −0·38 (95% CI: −0·49, −0·27)), and with higher scores for non-verbal IQ (difference 0·65 (95% CI: 0·41, 0·89)). As compared to term birth, preterm birth was associated with higher internalizing problems (difference 3·43 (95% CI: 2·52, 4·33)) and externalizing problems (difference 2·31 (95% CI: 1·16, 3·46)), ADHD symptoms (difference 4·15 (95% CI: 3·15, 5·16)), ASD symptoms (difference 3·23 (95% CI: 0·37, 6·08)), and lower non-verbal IQ (difference −5·44 (95% CI: −7·44, −3·44)). Small size for gestational age at birth (SGA) in comparison with appropriate size for gestational age (AGA) was associated with higher ADHD symptoms (difference 4·88 (95% CI: 3·87, 5·90)) and lower Non-verbal IQ (difference −7·02 (95% CI: −8·84, −5·21)). Large size for gestational age at birth was associated with lower ADHD symptoms (difference −1·09 (95% CI: −1·73, 0·45)) and higher non-verbal IQ (difference 2·47 (95% CI: 0·77, 4·18)). Explorative analyses showed that as compared to children with an appropriate size for gestational age at birth and a normal BMI at the age of 2 years, children born SGA who remained small at 2 years had the lowest non-verbal IQ score (difference −8·14 percentiles (95% CI: −11·89, −4·39)). Interpretation: Both fetal and early childhood growth are associated with emotional, behavioral and cognitive outcomes throughout childhood and adolescence. Compensatory infant growth might partly attenuate the adverse effects of suboptimal fetal growth. Future studies are needed to identify the potential for optimizing mental health outcomes in new generations by improving early-life growth. Funding: This project received funding from the European Union's Horizon 2020 research and innovation programme ( LIFECYCLE, grant agreement No 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583).
AB - Background: Fetal and infant development might be critical for cognitive outcomes and psychopathology later in life. We assessed the associations of birth characteristics and early life growth with behavior and cognitive outcomes from childhood to adolescence. Methods: We used harmonized data of 109,481 children from 8 European birth cohorts. Birth weight, gestational age, and body mass index (BMI) tertiles at the age of 2 years were used as the exposure variables. Outcomes included internalizing and externalizing problems and attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and non-verbal intelligence quotient (Non-verbal IQ) in childhood (4–10 years), early adolescence (11–16 years), and late adolescence (17–20 years). We used 1-stage individual participant data meta-analyses using generalized linear models. Findings: A one-week older gestational age was associated with lower scores for internalizing problems (difference −0·48 (95% CI: −0·59, −0·37)), externalizing problems (difference −0·34 (95% CI: −0·44, −0·23)), and ADHD symptoms (difference −0·38 (95% CI: −0·49, −0·27)), and with higher scores for non-verbal IQ (difference 0·65 (95% CI: 0·41, 0·89)). As compared to term birth, preterm birth was associated with higher internalizing problems (difference 3·43 (95% CI: 2·52, 4·33)) and externalizing problems (difference 2·31 (95% CI: 1·16, 3·46)), ADHD symptoms (difference 4·15 (95% CI: 3·15, 5·16)), ASD symptoms (difference 3·23 (95% CI: 0·37, 6·08)), and lower non-verbal IQ (difference −5·44 (95% CI: −7·44, −3·44)). Small size for gestational age at birth (SGA) in comparison with appropriate size for gestational age (AGA) was associated with higher ADHD symptoms (difference 4·88 (95% CI: 3·87, 5·90)) and lower Non-verbal IQ (difference −7·02 (95% CI: −8·84, −5·21)). Large size for gestational age at birth was associated with lower ADHD symptoms (difference −1·09 (95% CI: −1·73, 0·45)) and higher non-verbal IQ (difference 2·47 (95% CI: 0·77, 4·18)). Explorative analyses showed that as compared to children with an appropriate size for gestational age at birth and a normal BMI at the age of 2 years, children born SGA who remained small at 2 years had the lowest non-verbal IQ score (difference −8·14 percentiles (95% CI: −11·89, −4·39)). Interpretation: Both fetal and early childhood growth are associated with emotional, behavioral and cognitive outcomes throughout childhood and adolescence. Compensatory infant growth might partly attenuate the adverse effects of suboptimal fetal growth. Future studies are needed to identify the potential for optimizing mental health outcomes in new generations by improving early-life growth. Funding: This project received funding from the European Union's Horizon 2020 research and innovation programme ( LIFECYCLE, grant agreement No 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583).
UR - http://www.scopus.com/inward/record.url?scp=85218855385&partnerID=8YFLogxK
U2 - 10.1016/j.lanepe.2025.101247
DO - 10.1016/j.lanepe.2025.101247
M3 - Article
AN - SCOPUS:85218855385
SN - 2666-7762
VL - 52
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 101247
ER -