Early life immune system development: Impact of IBD and immunomodulation in pregnancy

Jantina Bolt-Wieringa

Early life immune system development: Impact of IBD and immunomodulation in pregnancy

Jantina Bolt-Wieringa

Pediatrics

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

Current guidelines for inflammatory bowel disease advise to continue immunomodulating medication during pregnancy to ensure disease remission. However the possible effects of intra uterine exposure to these medications on the infants developing immune system remain uncertain. In this thesis we investigated the impact of maternal IBD and immunomodulating medication on the response to maternal Tdap vaccination, infants' active immunization and drug clearance of different biologicals. Additionally we explored the immunological composition of breastmilk and the role of microbiome in IBD pathogenesis.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	van der Woude, C. Janneke, Supervisor Driessen, Gertjan J.A. , Supervisor Fuhler, Gwenny, Co-supervisor
Award date	7 Nov 2024
Place of Publication	Rotterdam
Print ISBNs	978-94-6506-449-9
Publication status	Published - 7 Nov 2024

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Cite this

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title = "Early life immune system development: Impact of IBD and immunomodulation in pregnancy",

abstract = "Current guidelines for inflammatory bowel disease advise to continue immunomodulating medication during pregnancy to ensure disease remission. However the possible effects of intra uterine exposure to these medications on the infants developing immune system remain uncertain. In this thesis we investigated the impact of maternal IBD and immunomodulating medication on the response to maternal Tdap vaccination, infants' active immunization and drug clearance of different biologicals. Additionally we explored the immunological composition of breastmilk and the role of microbiome in IBD pathogenesis.",

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TY - BOOK

T1 - Early life immune system development

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AU - Bolt-Wieringa, Jantina

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N2 - Current guidelines for inflammatory bowel disease advise to continue immunomodulating medication during pregnancy to ensure disease remission. However the possible effects of intra uterine exposure to these medications on the infants developing immune system remain uncertain. In this thesis we investigated the impact of maternal IBD and immunomodulating medication on the response to maternal Tdap vaccination, infants' active immunization and drug clearance of different biologicals. Additionally we explored the immunological composition of breastmilk and the role of microbiome in IBD pathogenesis.

AB - Current guidelines for inflammatory bowel disease advise to continue immunomodulating medication during pregnancy to ensure disease remission. However the possible effects of intra uterine exposure to these medications on the infants developing immune system remain uncertain. In this thesis we investigated the impact of maternal IBD and immunomodulating medication on the response to maternal Tdap vaccination, infants' active immunization and drug clearance of different biologicals. Additionally we explored the immunological composition of breastmilk and the role of microbiome in IBD pathogenesis.

M3 - Doctoral Thesis

SN - 978-94-6506-449-9

CY - Rotterdam

ER -

Early life immune system development: Impact of IBD and immunomodulation in pregnancy

Abstract

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