Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis

Marco Goeijenbier; Jeroen van Kampen; Chantal Reusken; Marion Koopmans; Eric van Gorp

Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis

Marco Goeijenbier, Jeroen van Kampen, Chantal Reusken, Marion Koopmans, Eric van Gorp

Virology

Research output: Contribution to journal › Article › Academic › peer-review

82 Citations (Scopus)

Abstract

Currently, West Africa is facing the largest outbreak of Ebola virus disease (EVD) in history. The virus causing this outbreak, the Zaire Ebolavirus (EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to 90% have been reported. Mortality is the result of multi-organ failure and severe bleeding complications. By 18 September 2014, the WHO reported of 5335 cases (confirmed, suspected and probable) with 2622 deaths, resulting in a case fatality rate of around 50%. This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.

Original language	Undefined/Unknown
Pages (from-to)	442-448
Number of pages	7
Journal	Netherlands Journal of Medicine
Volume	72
Issue number	9
Publication status	Published - 2014

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Cite this

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title = "Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis",

abstract = "Currently, West Africa is facing the largest outbreak of Ebola virus disease (EVD) in history. The virus causing this outbreak, the Zaire Ebolavirus (EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to 90% have been reported. Mortality is the result of multi-organ failure and severe bleeding complications. By 18 September 2014, the WHO reported of 5335 cases (confirmed, suspected and probable) with 2622 deaths, resulting in a case fatality rate of around 50%. This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.",

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year = "2014",

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T1 - Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis

AU - Goeijenbier, Marco

AU - van Kampen, Jeroen

AU - Reusken, Chantal

AU - Koopmans, Marion

AU - van Gorp, Eric

PY - 2014

Y1 - 2014

N2 - Currently, West Africa is facing the largest outbreak of Ebola virus disease (EVD) in history. The virus causing this outbreak, the Zaire Ebolavirus (EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to 90% have been reported. Mortality is the result of multi-organ failure and severe bleeding complications. By 18 September 2014, the WHO reported of 5335 cases (confirmed, suspected and probable) with 2622 deaths, resulting in a case fatality rate of around 50%. This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.

AB - Currently, West Africa is facing the largest outbreak of Ebola virus disease (EVD) in history. The virus causing this outbreak, the Zaire Ebolavirus (EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to 90% have been reported. Mortality is the result of multi-organ failure and severe bleeding complications. By 18 September 2014, the WHO reported of 5335 cases (confirmed, suspected and probable) with 2622 deaths, resulting in a case fatality rate of around 50%. This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.

M3 - Article

SN - 0300-2977

VL - 72

SP - 442

EP - 448

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 9

ER -