Effect of thiopentone, etomidate and propofol on systemic vascular resistance during cardiopulmonary bypass

F. Boer*, J. G. Bovill, P. Ros, H. Van Ommen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

We have studied the effect of thiopentone, etomidate and propofol on systemic vascular resistance (SVR) during cardiopulmonary bypass with constant pump flow in 30 patients undergoing elective coronary artery bypass surgery. SVR decreased to 78% of control values after thiopentone 4 mg kg-1, to 72% of control after etomidate 0.3 mg kg-1, and to 68% of control after propofol 2 mg kg-1; it returned to control values 10 min after administration of thiopentone and propofol and 7 min after administration of etomidate. Analysis of variance showed that there were no significant differences in the changes in SVR between the groups.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalBritish Journal of Anaesthesia
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 1991
Externally publishedYes

Bibliographical note

Funding Information:
The authors are grateful to ICI-Farma, Rotterdam, Netherlands for financial support.

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