Effect of Water T2 Shortening in the Quantification of in-vitro Proton MR Spectroscopy

Juan Antonio Hernández-Tamames, Virginia Mato Abad*, Roberto García-Álvarez, Javier González-Zabaleta, Javier Pereira Loureiro, Juan Álvarez-Linera

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


PURPOSE: This work studies the relationship between in-vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay. MATERIALS AND METHODS: An in-vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios. RESULTS: The Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios. CONCLUSION: These results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in-vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter-subject variability in the metabolite concentration and ratio quantification.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalJournal of Neuroimaging
Issue number1
Publication statusPublished - Jan 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 by the American Society of Neuroimaging.


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