Effect of wavelength and light-dose in photodynamic therapy of the normal rat oesophagus with ALA-induced photosensibilization

JC Boogert - Kluin, Ron de Bruin, HJ Staveren, PD (Peter) Siersema, R (Richard) van Hillegersberg

Research output: Contribution to journalConference articleAcademic

1 Citation (Scopus)

Abstract

Sixty rats received 200 mg/kg 5-aminolevulinic acid (ALA) orally, and ten untreated rats served as controls. In groups of five rats, the esophagus was illuminated with red or green light three hours after ALA administration. During illumination, fluorescence in the esophagus was measured. The efficacy of ALA-photodynamic therapy depended on the wavelength and illumination scheme. The best results were obtained using a red light in a power setting of 33 mW/cm. The optimal light-dose may lie between 8.3 and 25 J/cm.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3563
DOIs
Publication statusPublished - 1998
EventProceedings of the 1998 Photochemotherapy of Cancer and Other Diseases - Stockholm, SWE
Duration: 9 Sept 199811 Sept 1998

Research programs

  • EMC MM-03-47-06-A

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