Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid

Arjen Jongste, Marieke Graaf, Patricia Broek, Jaco Kraan, Peter Sillevis Smitt, Jan willem Gratama

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3 Citations (Scopus)

Abstract

Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carrying individuals, we characterized CD4+ and CD8+ T-cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non-carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals. (c) 2013 International Clinical Cytometry Society
Original languageUndefined/Unknown
Pages (from-to)218-221
Number of pages4
JournalCytometry Part B-Clinical Cytometry
Volume84B
Issue number4
DOIs
Publication statusPublished - 2013

Research programs

  • EMC MM-03-44-06

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