Abstract
Cerebral perfusion dysfunctions are seen in the early stages of Alzheimer’s disease (AD). We systematically
reviewed the literature to investigate the effect of pharmacological and non-pharmacological interventions on
cerebral hemodynamics in randomized controlled trials involving AD patients or Mild Cognitive Impairment
(MCI) due to AD. Studies involving other dementia types were excluded. Data was searched in April 2021 on
MEDLINE, Embase, and Web of Science. Risk of bias was assessed using Cochrane Risk of Bias Tool. A metasynthesis was performed separating results from MCI and AD studies. 31 studies were included and involved
310 MCI and 792 CE patients. The MCI studies (n = 8) included physical, cognitive, dietary, and pharmacological
interventions. The AD studies (n = 23) included pharmacological, physical interventions, and phytotherapy.
Cerebral perfusion was assessed with PET, ASL, Doppler, fNIRS, DSC-MRI, Xe-CT, and SPECT. Randomization
and allocation concealment methods and subject characteristics such as AD-onset, education, and ethnicity were
missing in several papers. Positive effects on hemodynamics were seen in 75 % of the MCI studies, and 52 % of
the AD studies. Inserting cerebral perfusion outcome measures, together with established AD biomarkers, is
fundamental to target all disease mechanisms and understand the role of cerebral perfusion in AD.
reviewed the literature to investigate the effect of pharmacological and non-pharmacological interventions on
cerebral hemodynamics in randomized controlled trials involving AD patients or Mild Cognitive Impairment
(MCI) due to AD. Studies involving other dementia types were excluded. Data was searched in April 2021 on
MEDLINE, Embase, and Web of Science. Risk of bias was assessed using Cochrane Risk of Bias Tool. A metasynthesis was performed separating results from MCI and AD studies. 31 studies were included and involved
310 MCI and 792 CE patients. The MCI studies (n = 8) included physical, cognitive, dietary, and pharmacological
interventions. The AD studies (n = 23) included pharmacological, physical interventions, and phytotherapy.
Cerebral perfusion was assessed with PET, ASL, Doppler, fNIRS, DSC-MRI, Xe-CT, and SPECT. Randomization
and allocation concealment methods and subject characteristics such as AD-onset, education, and ethnicity were
missing in several papers. Positive effects on hemodynamics were seen in 75 % of the MCI studies, and 52 % of
the AD studies. Inserting cerebral perfusion outcome measures, together with established AD biomarkers, is
fundamental to target all disease mechanisms and understand the role of cerebral perfusion in AD.
| Original language | English |
|---|---|
| Article number | 101661 |
| Journal | Ageing Research Reviews |
| Volume | 79 |
| DOIs | |
| Publication status | Published - Aug 2022 |
Bibliographical note
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