Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers

Maartje Luijten; DA O'Connor; S Rossiter; Ingmar Franken; R Hester

doi:10.1111/add.12276

Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers

Maartje Luijten, DA O'Connor, S Rossiter, Ingmar Franken, R Hester

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

Background and aimsSusceptibility to use of addictive substances may result, in part, from a greater preference for an immediate small reward relative to a larger delayed reward or relative insensitivity to punishment. This functional magnetic resonance imaging (fMRI) study examined the neural basis of inhibiting an immediately rewarding stimulus to obtain a larger delayed reward in smokers. We also investigated whether punishment could modulate inhibitory control. DesignThe Monetary Incentive Go/NoGo (MI-Go/NoGo) task was administered that provided three types of reward outcomes contingent upon inhibitory control performance over rewarding stimuli: inhibition failure was either followed by no monetary reward (neutral condition), a small monetary reward with immediate feedback (reward condition) or immediate monetary punishment (punishment condition). In the reward and punishment conditions, successful inhibitory control resulted in larger delayed rewards. SettingCommunity sample of smokers in the Melbourne (Australia) area. ParticipantsNineteen smokers were compared with 17 demographically matched non-smoking controls. MeasurementsAccuracy, reaction times and brain activation associated with the MI-Go/NoGo task. FindingsSmokers showed hyperactivation in the right insula (P<0.01), inferior and middle frontal gyrus (P<0.01), dorsolateral prefrontal cortex (P=0.001) and inferior parietal lobe (P<0.01) both during inhibition of an immediately rewarding stimulus to obtain a larger delayed reward, and during inhibition of neutral stimuli. Group differences in brain activity were not significant in the punishment condition in the right insula and dorsolateral prefrontal cortex, most probably as a result of inc ConclusionsCompared with non-smokers, smokers showed increased neural activation when resisting immediately rewarding stimuli and may be less sensitive to punishment as a strategy to increase control over rewarding stimuli.

Original language	English
Pages (from-to)	1969-1978
Number of pages	10
Journal	Addiction
Volume	108
Issue number	11
DOIs	https://doi.org/10.1111/add.12276
Publication status	Published - 2013

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10.1111/add.12276

http://hdl.handle.net/1765/41685

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title = "Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers",

abstract = "Background and aimsSusceptibility to use of addictive substances may result, in part, from a greater preference for an immediate small reward relative to a larger delayed reward or relative insensitivity to punishment. This functional magnetic resonance imaging (fMRI) study examined the neural basis of inhibiting an immediately rewarding stimulus to obtain a larger delayed reward in smokers. We also investigated whether punishment could modulate inhibitory control. DesignThe Monetary Incentive Go/NoGo (MI-Go/NoGo) task was administered that provided three types of reward outcomes contingent upon inhibitory control performance over rewarding stimuli: inhibition failure was either followed by no monetary reward (neutral condition), a small monetary reward with immediate feedback (reward condition) or immediate monetary punishment (punishment condition). In the reward and punishment conditions, successful inhibitory control resulted in larger delayed rewards. SettingCommunity sample of smokers in the Melbourne (Australia) area. ParticipantsNineteen smokers were compared with 17 demographically matched non-smoking controls. MeasurementsAccuracy, reaction times and brain activation associated with the MI-Go/NoGo task. FindingsSmokers showed hyperactivation in the right insula (P<0.01), inferior and middle frontal gyrus (P<0.01), dorsolateral prefrontal cortex (P=0.001) and inferior parietal lobe (P<0.01) both during inhibition of an immediately rewarding stimulus to obtain a larger delayed reward, and during inhibition of neutral stimuli. Group differences in brain activity were not significant in the punishment condition in the right insula and dorsolateral prefrontal cortex, most probably as a result of inc ConclusionsCompared with non-smokers, smokers showed increased neural activation when resisting immediately rewarding stimuli and may be less sensitive to punishment as a strategy to increase control over rewarding stimuli.",

author = "Maartje Luijten and DA O'Connor and S Rossiter and Ingmar Franken and R Hester",

year = "2013",

doi = "10.1111/add.12276",

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T1 - Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers

AU - Luijten, Maartje

AU - O'Connor, DA

AU - Rossiter, S

AU - Franken, Ingmar

AU - Hester, R

PY - 2013

Y1 - 2013

N2 - Background and aimsSusceptibility to use of addictive substances may result, in part, from a greater preference for an immediate small reward relative to a larger delayed reward or relative insensitivity to punishment. This functional magnetic resonance imaging (fMRI) study examined the neural basis of inhibiting an immediately rewarding stimulus to obtain a larger delayed reward in smokers. We also investigated whether punishment could modulate inhibitory control. DesignThe Monetary Incentive Go/NoGo (MI-Go/NoGo) task was administered that provided three types of reward outcomes contingent upon inhibitory control performance over rewarding stimuli: inhibition failure was either followed by no monetary reward (neutral condition), a small monetary reward with immediate feedback (reward condition) or immediate monetary punishment (punishment condition). In the reward and punishment conditions, successful inhibitory control resulted in larger delayed rewards. SettingCommunity sample of smokers in the Melbourne (Australia) area. ParticipantsNineteen smokers were compared with 17 demographically matched non-smoking controls. MeasurementsAccuracy, reaction times and brain activation associated with the MI-Go/NoGo task. FindingsSmokers showed hyperactivation in the right insula (P<0.01), inferior and middle frontal gyrus (P<0.01), dorsolateral prefrontal cortex (P=0.001) and inferior parietal lobe (P<0.01) both during inhibition of an immediately rewarding stimulus to obtain a larger delayed reward, and during inhibition of neutral stimuli. Group differences in brain activity were not significant in the punishment condition in the right insula and dorsolateral prefrontal cortex, most probably as a result of inc ConclusionsCompared with non-smokers, smokers showed increased neural activation when resisting immediately rewarding stimuli and may be less sensitive to punishment as a strategy to increase control over rewarding stimuli.

AB - Background and aimsSusceptibility to use of addictive substances may result, in part, from a greater preference for an immediate small reward relative to a larger delayed reward or relative insensitivity to punishment. This functional magnetic resonance imaging (fMRI) study examined the neural basis of inhibiting an immediately rewarding stimulus to obtain a larger delayed reward in smokers. We also investigated whether punishment could modulate inhibitory control. DesignThe Monetary Incentive Go/NoGo (MI-Go/NoGo) task was administered that provided three types of reward outcomes contingent upon inhibitory control performance over rewarding stimuli: inhibition failure was either followed by no monetary reward (neutral condition), a small monetary reward with immediate feedback (reward condition) or immediate monetary punishment (punishment condition). In the reward and punishment conditions, successful inhibitory control resulted in larger delayed rewards. SettingCommunity sample of smokers in the Melbourne (Australia) area. ParticipantsNineteen smokers were compared with 17 demographically matched non-smoking controls. MeasurementsAccuracy, reaction times and brain activation associated with the MI-Go/NoGo task. FindingsSmokers showed hyperactivation in the right insula (P<0.01), inferior and middle frontal gyrus (P<0.01), dorsolateral prefrontal cortex (P=0.001) and inferior parietal lobe (P<0.01) both during inhibition of an immediately rewarding stimulus to obtain a larger delayed reward, and during inhibition of neutral stimuli. Group differences in brain activity were not significant in the punishment condition in the right insula and dorsolateral prefrontal cortex, most probably as a result of inc ConclusionsCompared with non-smokers, smokers showed increased neural activation when resisting immediately rewarding stimuli and may be less sensitive to punishment as a strategy to increase control over rewarding stimuli.

U2 - 10.1111/add.12276

DO - 10.1111/add.12276

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VL - 108

SP - 1969

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JO - Addiction

JF - Addiction

IS - 11

ER -

Effects of reward and punishment on brain activations associated with inhibitory control in cigarette smokers

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