Efficacy and Long-term Outcomes of Repeated Large Loop Excision of the Transformation Zone of the Cervix

Anna J.M. van de Sande*, Coen M. Schreuder, Romy van Baars, Margot M. Koeneman, Cornelis G. Gerestein, Arnold Jan Kruse, Folkert J. van Kemenade, Sten P. Willemsen, Heleen J. van Beekhuizen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

OBJECTIVE: To evaluate the efficacy and long-term outcome of repeat large loop excision of the transformation zone in women with residual or recurrent cervical intraepithelial neoplasia. METHODS: PALGA (the Dutch Pathology Registry), a database of deidentified cervical cytologic and histologic data, was used to examine women with cervical dysplasia who underwent two or more large loop excision of the transformation zone procedures between January 2005 and June 2015. We obtained cervical cytology and histology results. The main outcome was efficacy of repeated large loop excision of the transformation zone procedure in women with residual or recurrent cervical intraepithelial neoplasia. We also examined subsequent excisional procedures and hysterectomy. RESULTS: We identified 499 women who had undergone two or more large loop excision of the transformation zone procedures. After their second procedure, 60.7% of women had a normal first cervical cytologic sample. The mean duration of follow-up was 68 months (0-163 months). Additional cervical excisional procedures were performed in 33.7% of women. Overall, 1.2% of women developed cervical cancer during follow-up. Moreover, 19.0% of women eventually underwent hysterectomy. CONCLUSION: One third of the women who undergo two large loop excision of the transformation zone procedures require an additional excisional procedure or hysterectomy. Almost one fifth of these women eventually undergo hysterectomy.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalObstetrics and Gynecology
Volume139
Issue number3
DOIs
Publication statusPublished - 1 Mar 2022

Bibliographical note

Publisher Copyright: Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

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