Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

M Roestenberg, Sake de Vlas, AE Nieman, RW Sauerwein, CC Hermsen

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36 Citations (Scopus)

Abstract

The development of a vaccine against malaria has public health priority. In a controlled setting, preliminary data on the efficacy of Plasmodium falciparum vaccine candidates can be obtained by exposing immunized human volunteers to the bites of laboratory-reared P. falciparum-infected mosquitoes. Using empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction. Sporozoite challenge trials are thus a powerful tool for early selection of candidates that warrant efficacy of trials in the field.
Original languageUndefined/Unknown
Pages (from-to)319-323
Number of pages5
JournalJournal of Infectious Diseases
Volume206
Issue number3
DOIs
Publication statusPublished - 2012

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