Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values

Samuel Arends*, Judith Drenthen, the IGOS Consortium, Peter van den Bergh, Hessel Franssen, Robert D.M. Hadden, B. Islam, Satoshi Kuwabara, Ricardo C. Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H. Brannagan, Jan Buermann, Carlos CasasnovasGuido Cavaletti, Chi Chao Chao, Mazen M. Dimachkie, Ernesto A. Fulgenzi, Christine Verboon, B. C. Jacobs, David R. Cornblath

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)


Objective: To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). Methods: Prospectively collected clinical and EDx data were available in 957 IGOS patients from 115 centers. Only the first EDx study was included in the current analysis. Results: Median timing of the EDx study was 7 days (interquartile range 4–11) from symptom onset. Methodology varied between centers, countries and regions. Reference values from the responding 103 centers were derived locally in 49%, from publications in 37% and from a combination of these in the remaining 15%. Amplitude measurement in the EDx studies (baseline-to-peak or peak-to-peak) differed from the way this was done in the reference values, in 22% of motor and 39% of sensory conduction. There was marked variability in both motor and sensory reference values, although only a few outliers accounted for this. Conclusions: Our study showed extensive variation in the clinical practice of EDx in GBS patients among IGOS centers across the regions. Significance: Besides EDx variation in GBS patients participating in IGOS, this diversity is likely to be present in other neuromuscular disorders and centers. This underlines the need for standardization of EDx in future multinational GBS studies.

Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalClinical Neurophysiology
Publication statusPublished - Jun 2022

Bibliographical note

Funding Information:
The IGOS was funded by the -CIDP Foundation International, gain, University Medical Center, Glasgow University, Prinses Beatrix Spierfonds, CSL Behring, Grifols, Annexon and Hansa Biopharma. Study sponsors had no involvement in data collection, analysis, interpretation and/or writing of the manuscript.

Publisher Copyright:
© 2022 International Federation of Clinical Neurophysiology


Dive into the research topics of 'Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values'. Together they form a unique fingerprint.

Cite this