TY - JOUR
T1 - Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study
T2 - Differences in methods and reference values
AU - Arends, Samuel
AU - Drenthen, Judith
AU - the IGOS Consortium
AU - van den Bergh, Peter
AU - Franssen, Hessel
AU - Hadden, Robert D.M.
AU - Islam, B.
AU - Kuwabara, Satoshi
AU - Reisin, Ricardo C.
AU - Shahrizaila, Nortina
AU - Amino, Hiroshi
AU - Antonini, Giovanni
AU - Attarian, Shahram
AU - Balducci, Claudia
AU - Barroso, Fabio
AU - Bertorini, Tulio
AU - Binda, Davide
AU - Brannagan, Thomas H.
AU - Buermann, Jan
AU - Casasnovas, Carlos
AU - Cavaletti, Guido
AU - Chao, Chi Chao
AU - Dimachkie, Mazen M.
AU - Fulgenzi, Ernesto A.
AU - Verboon, Christine
AU - Jacobs, B. C.
AU - Cornblath, David R.
N1 - Funding Information:
The IGOS was funded by the -CIDP Foundation International, gain, University Medical Center, Glasgow University, Prinses Beatrix Spierfonds, CSL Behring, Grifols, Annexon and Hansa Biopharma. Study sponsors had no involvement in data collection, analysis, interpretation and/or writing of the manuscript.
Publisher Copyright:
© 2022 International Federation of Clinical Neurophysiology
PY - 2022/6
Y1 - 2022/6
N2 - Objective: To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). Methods: Prospectively collected clinical and EDx data were available in 957 IGOS patients from 115 centers. Only the first EDx study was included in the current analysis. Results: Median timing of the EDx study was 7 days (interquartile range 4–11) from symptom onset. Methodology varied between centers, countries and regions. Reference values from the responding 103 centers were derived locally in 49%, from publications in 37% and from a combination of these in the remaining 15%. Amplitude measurement in the EDx studies (baseline-to-peak or peak-to-peak) differed from the way this was done in the reference values, in 22% of motor and 39% of sensory conduction. There was marked variability in both motor and sensory reference values, although only a few outliers accounted for this. Conclusions: Our study showed extensive variation in the clinical practice of EDx in GBS patients among IGOS centers across the regions. Significance: Besides EDx variation in GBS patients participating in IGOS, this diversity is likely to be present in other neuromuscular disorders and centers. This underlines the need for standardization of EDx in future multinational GBS studies.
AB - Objective: To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). Methods: Prospectively collected clinical and EDx data were available in 957 IGOS patients from 115 centers. Only the first EDx study was included in the current analysis. Results: Median timing of the EDx study was 7 days (interquartile range 4–11) from symptom onset. Methodology varied between centers, countries and regions. Reference values from the responding 103 centers were derived locally in 49%, from publications in 37% and from a combination of these in the remaining 15%. Amplitude measurement in the EDx studies (baseline-to-peak or peak-to-peak) differed from the way this was done in the reference values, in 22% of motor and 39% of sensory conduction. There was marked variability in both motor and sensory reference values, although only a few outliers accounted for this. Conclusions: Our study showed extensive variation in the clinical practice of EDx in GBS patients among IGOS centers across the regions. Significance: Besides EDx variation in GBS patients participating in IGOS, this diversity is likely to be present in other neuromuscular disorders and centers. This underlines the need for standardization of EDx in future multinational GBS studies.
UR - http://www.scopus.com/inward/record.url?scp=85123384705&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2021.12.014
DO - 10.1016/j.clinph.2021.12.014
M3 - Article
C2 - 35078730
AN - SCOPUS:85123384705
VL - 138
SP - 231
EP - 240
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
ER -