TY - JOUR
T1 - Electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration in children, an exploratory observational study
AU - de Heer, Iris J.
AU - Raab, Hannah A.C.
AU - Krul, Stephan
AU - Karaöz-Bulut, Gulhan
AU - Stolker, Robert Jan
AU - Weber, Frank
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2024/4
Y1 - 2024/4
N2 - Introduction: Propofol and sevoflurane have a long history in pediatric anesthesia. Combining both drugs at low dose levels offers new opportunities. However, monitoring the hypnotic effects of this drug combination in children is challenging, because the currently available processed EEG-based systems are insufficiently validated in young children and the co-administration of anesthetics. This study investigated electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration with fixed sevoflurane- and variable propofol dosages. Patients and methods: We analyzed the density spectral array pattern recorded during propofol/sevoflurane anesthesia in pediatric patients from birth to 11 years of age. Data from 78 patients were suitable for analysis. The primary outcome parameter of this study was the correlation between variable propofol dosages and the expression of the four electroencephalogram frequency bands β, α, θ, and δ. The main secondary outcome parameters were the intra-operative total EEG power and the prevalence of burst suppression. Results: In patients above the age of 1 year, a dose-dependent correlation between the propofol dosage and the relative percentage of β (−12.2%, p < 0.001) and δ (5.1%, p < 0.001) was found. There was an age-dependent trend toward increasing mean EEG power, with the most significant increase in the first year of life. In 14.1% of our patients, at least one episode of burst suppression occurred. Conclusion: DSA-guided augmentation of propofol anesthesia with sevoflurane provides sufficient depth of anesthesia at doses usually considered sub-anesthetic in children, leading to less anesthetic drug exposure for the individual child.
AB - Introduction: Propofol and sevoflurane have a long history in pediatric anesthesia. Combining both drugs at low dose levels offers new opportunities. However, monitoring the hypnotic effects of this drug combination in children is challenging, because the currently available processed EEG-based systems are insufficiently validated in young children and the co-administration of anesthetics. This study investigated electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration with fixed sevoflurane- and variable propofol dosages. Patients and methods: We analyzed the density spectral array pattern recorded during propofol/sevoflurane anesthesia in pediatric patients from birth to 11 years of age. Data from 78 patients were suitable for analysis. The primary outcome parameter of this study was the correlation between variable propofol dosages and the expression of the four electroencephalogram frequency bands β, α, θ, and δ. The main secondary outcome parameters were the intra-operative total EEG power and the prevalence of burst suppression. Results: In patients above the age of 1 year, a dose-dependent correlation between the propofol dosage and the relative percentage of β (−12.2%, p < 0.001) and δ (5.1%, p < 0.001) was found. There was an age-dependent trend toward increasing mean EEG power, with the most significant increase in the first year of life. In 14.1% of our patients, at least one episode of burst suppression occurred. Conclusion: DSA-guided augmentation of propofol anesthesia with sevoflurane provides sufficient depth of anesthesia at doses usually considered sub-anesthetic in children, leading to less anesthetic drug exposure for the individual child.
UR - http://www.scopus.com/inward/record.url?scp=85182373502&partnerID=8YFLogxK
U2 - 10.1016/j.accpm.2023.101342
DO - 10.1016/j.accpm.2023.101342
M3 - Article
C2 - 38142866
AN - SCOPUS:85182373502
SN - 0750-7658
VL - 43
JO - Anaesthesia Critical Care and Pain Medicine
JF - Anaesthesia Critical Care and Pain Medicine
IS - 2
M1 - 101342
ER -