Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

Arjen Jongste; Marieke Graaf; Patricia Broek; Jaco Kraan; Peter Sillevis Smitt; Jan willem Gratama

doi:10.1016/j.jneuroim.2013.02.006

Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

Arjen Jongste, Marieke Graaf, Patricia Broek, Jaco Kraan, Peter Sillevis Smitt, Jan willem Gratama

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. (C) 2013 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	85-90
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	258
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.02.006
Publication status	Published - 2013

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10.1016/j.jneuroim.2013.02.006

http://hdl.handle.net/1765/39849

Cite this

Jongste, A., Graaf, M., Broek, P., Kraan, J., Sillevis Smitt, P., & Gratama, J. W. (2013). Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes. Journal of Neuroimmunology, 258(1-2), 85-90. https://doi.org/10.1016/j.jneuroim.2013.02.006

Jongste, Arjen ; Graaf, Marieke ; Broek, Patricia ; Kraan, Jaco ; Sillevis Smitt, Peter ; Gratama, Jan willem. / Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes. In: Journal of Neuroimmunology. 2013 ; Vol. 258, No. 1-2. pp. 85-90.

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title = "Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes",

abstract = "Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. (C) 2013 Elsevier B.V. All rights reserved.",

author = "Arjen Jongste and Marieke Graaf and Patricia Broek and Jaco Kraan and {Sillevis Smitt}, Peter and Gratama, {Jan willem}",

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Jongste, A, Graaf, M, Broek, P, Kraan, J , Sillevis Smitt, P & Gratama, JW 2013, 'Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes', Journal of Neuroimmunology, vol. 258, no. 1-2, pp. 85-90. https://doi.org/10.1016/j.jneuroim.2013.02.006

Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes. / Jongste, Arjen; Graaf, Marieke; Broek, Patricia; Kraan, Jaco ; Sillevis Smitt, Peter ; Gratama, Jan willem.

In: Journal of Neuroimmunology, Vol. 258, No. 1-2, 2013, p. 85-90.

Research output: Contribution to journal › Article › Academic › peer-review

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AB - Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. (C) 2013 Elsevier B.V. All rights reserved.

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