Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

Arjen Jongste, Marieke Graaf, Patricia Broek, Jaco Kraan, Peter Sillevis Smitt, Jan willem Gratama

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12 Citations (Scopus)

Abstract

Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. (C) 2013 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)85-90
Number of pages6
JournalJournal of Neuroimmunology
Volume258
Issue number1-2
DOIs
Publication statusPublished - 2013

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