Emergence and Potential Extinction of Genetic Lineages of Human Metapneumovirus between 2005 and 2021

Kevin Groen, Stefan Van Nieuwkoop, Adam Meijer, Bas Van Der Veer, Jeroen J.A. van Kampen, Pieter L. Fraaij, Ron A.M. Fouchier, Bernadette G. Van Den Hoogen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
34 Downloads (Pure)

Abstract

Human metapneumovirus (HMPV) is one of the leading causes of respiratory illness (RI), primarily in infants. Worldwide, two genetic lineages (A and B) of HMPV are circulating that are antigenically distinct and can each be further divided into genetic sublineages. Surveillance combined with large-scale whole-genome sequencing studies of HMPV are scarce but would help to identify viral evolutionary dynamics. Here, we analyzed 130 whole HMPV genome sequences obtained from samples collected from individuals hospitalized with RI and partial fusion (n = 144) and attachment (n = 123) protein gene sequences obtained from samples collected from patients with RI visiting general practitioners between 2005 and 2021 in the Netherlands. Phylogenetic analyses demonstrated that HMPV continued to group in the four sublineages described in 2004 (A1, A2, B1, and B2). However, one sublineage (A1) was no longer detected in the Netherlands after 2006, while the others continued to evolve. No differences were observed in dominant (sub)lineages between samples obtained from patients with RI being hospitalized and those consulting general practitioners. In both populations, viruses of lineage A2 carrying a 180-nucleotide or 111-nucleotide duplication in the attachment protein gene became the most frequently detected genotypes. In the past, different names for the newly energing lineages have been proposed, demonstrating the need for a consistent naming convention. Here, criteria are proposed for the designation of new genetic lineages to aid in moving toward a systematic HMPV classification.

Original languageEnglish
JournalmBio
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 2023

Bibliographical note

Funding Information:
This work was supported in part by Horizon 2020 research and innovation program grant number 874735 (VEO) from the European Union. The Dutch Ministry of Health, Welfare and Sport funded the GP sentinel surveillance.

Publisher Copyright:
© 2022 Groen et al.

Fingerprint

Dive into the research topics of 'Emergence and Potential Extinction of Genetic Lineages of Human Metapneumovirus between 2005 and 2021'. Together they form a unique fingerprint.

Cite this