Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter

PA Lemos, V Farooq, CK Takimura, PS Gutierrez, R Vinnani, F Kolodgie, U Christians, AN Kharlamov, M Doshi, P Sojitra, H.M.M. van Beusekom, PWJC (Patrick) Serruys

Research output: Contribution to journalArticleAcademicpeer-review

84 Citations (Scopus)

Abstract

Drug-eluting stents have proven to be effective in reducing the risk of late restenosis. In order to achieve a controlled and prolonged release of the antiproliferative agent, current drug-eluting stents utilise various biodegradable as well as non-erodible polymeric blends to coat the stent surface and to serve as drug carriers. The utilisation of polymeric compounds in current drug-eluting stents may eventually limit their performance as well as their clinical applicability due to the potential induction of undesirable local reactions. The development of alternative, polymer-free drug carriers has the potential to overcome some of the limitations of current drug-eluting stent formulations. Moreover, improvements in drug carriers may also result in an expansion of the technological possibilities for other intravascular drug delivery systems, such as metal-free or even implant-free solutions. This article describes the structure and the preclinical validation profile of a novel phospholipid encapsulated sirolimus nanocarrier, used as a coating in two formulations: a coronary stent-plus-balloon system and a stand-alone balloon catheter. The nanoparticles provided a stable, even and homogenous coating to the devices in both formulations. Dose-finding studies allowed the most appropriate identification of the best nanoparticle structure associated with an extremely efficient transfer of
Original languageUndefined/Unknown
Pages (from-to)148-156
Number of pages9
JournalEuroIntervention
Volume9
Issue number1
DOIs
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09

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