Empirically Based Phenotypic Profiles of Children with Pervasive Developmental Disorders: Interpretation in the Light of the DSM-5

Kirstin Greaves-Lord, Mart Eussen, Frank Verhulst, RB (Ruud) Minderaa, W Mandy, James joseph Hudziak, MP Steenhuis, PF de Nijs, CA Hartman

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29 Citations (Scopus)


This study aimed to contribute to the Diagnostic and Statistical Manual (DSM) debates on the conceptualization of autism by investigating (1) whether empirically based distinct phenotypic profiles could be distinguished within a sample of mainly cognitively able children with pervasive developmental disorder (PDD), and (2) how profiles related to diagnoses and co-occurring behavioral and emotional problems. Six classes with distinct profiles were discerned. Three classes showed profiles not completely in line with the proposed DSM-5 conceptualization of autism. These classes included relatively many cognitively able individuals with PDD-not otherwise specified. However, profiles seemed to suit other diagnostic categories, such as social communication disorder. These alternative diagnoses could retain eligibility for services, and might adequately fit more specifically targeted interventions.
Original languageUndefined/Unknown
Pages (from-to)1784-1797
Number of pages14
JournalJournal of Autism and Developmental Disorders
Issue number8
Publication statusPublished - 2013

Research programs

  • EMC NIHES-04-55-01

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