EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology

Justo P. Castano; Mehul Tulsidas Dattani; Simona Grozinsky-Glasberg; Niki Karavitaki; Marianne E. Pavel; Cynthia Andoniadou; Krystallenia Alexandraki; Cristina Capatina; Manuela Cerbone; Diego Ferone; Hoong-Wei Gan; Johannes Hofland; Leo Hofland; Alejandro Ibanez-Costa; Mirela-Diana Ilie; Andrea M. Isidori; Marta Korbonits; Beata Kos-Kudla; Mohamad Maghnie; Giovanna Mantovani; Monica Marazuela; Gerald Raverot; Aldo Scarpa; Katharina Schilbach; Marily Theodoropoulou; Hanneke M. Van Santen; Maria Chiara Zatelli

doi:10.1159/000549145

EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology

Justo P. Castano
, Mehul Tulsidas Dattani
, Simona Grozinsky-Glasberg
, Niki Karavitaki
, Marianne E. Pavel
, Cynthia Andoniadou
, Krystallenia Alexandraki
, Cristina Capatina
, Manuela Cerbone
, Diego Ferone
, Hoong-Wei Gan
, Johannes Hofland
, Leo Hofland
, Alejandro Ibanez-Costa
, Mirela-Diana Ilie
, Andrea M. Isidori
, Marta Korbonits
, Beata Kos-Kudla
, Mohamad Maghnie
, Giovanna Mantovani

Monica Marazuela, Gerald Raverot, Aldo Scarpa, Katharina Schilbach, Marily Theodoropoulou, Hanneke M. Van Santen, Maria Chiara Zatelli

Internal Medicine

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Background:

Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

Methods:

Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

Results:

Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases.

Conclusions:

This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Original language	English
Pages (from-to)	105-120
Number of pages	16
Journal	Hormone Research in Paediatrics
Volume	98
Issue number	SUPPL 2
DOIs	https://doi.org/10.1159/000549145
Publication status	Published - Dec 2025

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). Published by S. Karger AG, Basel.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1159/000549145

Cite this

Castano, J. P., Dattani, M. T., Grozinsky-Glasberg, S., Karavitaki, N., Pavel, M. E., Andoniadou, C., Alexandraki, K., Capatina, C., Cerbone, M., Ferone, D., Gan, H.-W., Hofland, J., Hofland, L., Ibanez-Costa, A., Ilie, M.-D., Isidori, A. M., Korbonits, M., Kos-Kudla, B., Maghnie, M., ... Zatelli, M. C. (2025). EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology. Hormone Research in Paediatrics, 98(SUPPL 2), 105-120. https://doi.org/10.1159/000549145

@article{6fc13ddcf29642d3b30ef3271986006c,

title = "EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology",

abstract = "Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.",

author = "Castano, \{Justo P.\} and Dattani, \{Mehul Tulsidas\} and Simona Grozinsky-Glasberg and Niki Karavitaki and Pavel, \{Marianne E.\} and Cynthia Andoniadou and Krystallenia Alexandraki and Cristina Capatina and Manuela Cerbone and Diego Ferone and Hoong-Wei Gan and Johannes Hofland and Leo Hofland and Alejandro Ibanez-Costa and Mirela-Diana Ilie and Isidori, \{Andrea M.\} and Marta Korbonits and Beata Kos-Kudla and Mohamad Maghnie and Giovanna Mantovani and Monica Marazuela and Gerald Raverot and Aldo Scarpa and Katharina Schilbach and Marily Theodoropoulou and \{Van Santen\}, \{Hanneke M.\} and Zatelli, \{Maria Chiara\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Published by S. Karger AG, Basel.",

year = "2025",

month = dec,

doi = "10.1159/000549145",

language = "English",

volume = "98",

pages = "105--120",

journal = "Hormone Research in Paediatrics",

issn = "1663-2818",

publisher = "Karger",

number = "SUPPL 2",

}

Castano, JP, Dattani, MT, Grozinsky-Glasberg, S, Karavitaki, N, Pavel, ME, Andoniadou, C, Alexandraki, K, Capatina, C, Cerbone, M, Ferone, D, Gan, H-W, Hofland, J, Hofland, L, Ibanez-Costa, A, Ilie, M-D, Isidori, AM, Korbonits, M, Kos-Kudla, B, Maghnie, M, Mantovani, G, Marazuela, M, Raverot, G, Scarpa, A, Schilbach, K, Theodoropoulou, M, Van Santen, HM & Zatelli, MC 2025, 'EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology', Hormone Research in Paediatrics, vol. 98, no. SUPPL 2, pp. 105-120. https://doi.org/10.1159/000549145

TY - JOUR

T1 - EndoCompass Project

T2 - Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology

AU - Castano, Justo P.

AU - Dattani, Mehul Tulsidas

AU - Grozinsky-Glasberg, Simona

AU - Karavitaki, Niki

AU - Pavel, Marianne E.

AU - Andoniadou, Cynthia

AU - Alexandraki, Krystallenia

AU - Capatina, Cristina

AU - Cerbone, Manuela

AU - Ferone, Diego

AU - Gan, Hoong-Wei

AU - Hofland, Johannes

AU - Hofland, Leo

AU - Ibanez-Costa, Alejandro

AU - Ilie, Mirela-Diana

AU - Isidori, Andrea M.

AU - Korbonits, Marta

AU - Kos-Kudla, Beata

AU - Maghnie, Mohamad

AU - Mantovani, Giovanna

AU - Marazuela, Monica

AU - Raverot, Gerald

AU - Scarpa, Aldo

AU - Schilbach, Katharina

AU - Theodoropoulou, Marily

AU - Van Santen, Hanneke M.

AU - Zatelli, Maria Chiara

PY - 2025/12

Y1 - 2025/12

N2 - Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

AB - Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

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DO - 10.1159/000549145

M3 - Review article

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VL - 98

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EP - 120

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - SUPPL 2

ER -

EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology

Abstract

Bibliographical note

UN SDGs

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