Endogenous IFN lambda in Viral Hepatitis Patients

Rik Groen; F Mcphee; J Friborg; HLA Janssen; Andre Boonstra

doi:10.1089/jir.2013.0068

Endogenous IFN lambda in Viral Hepatitis Patients

Rik Groen, F Mcphee, J Friborg, HLA Janssen, Andre Boonstra

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

Besides type I interferons (IFNs), type III IFNs, including IFN lambda 1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFN lambda 3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFN lambda were observed between patient groups, disease stages, or clinical parameters.

Original language	Undefined/Unknown
Pages (from-to)	552-556
Number of pages	5
Journal	Journal of Interferon and Cytokine Research
Volume	34
Issue number	7
DOIs	https://doi.org/10.1089/jir.2013.0068
Publication status	Published - 2014

Research programs

EMC MM-04-20-01
EMC MM-04-20-02-A

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1089/jir.2013.0068

http://hdl.handle.net/1765/59932

Cite this

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abstract = "Besides type I interferons (IFNs), type III IFNs, including IFN lambda 1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFN lambda 3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFN lambda were observed between patient groups, disease stages, or clinical parameters.",

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T1 - Endogenous IFN lambda in Viral Hepatitis Patients

AU - Groen, Rik

AU - Mcphee, F

AU - Friborg, J

AU - Janssen, HLA

AU - Boonstra, Andre

PY - 2014

Y1 - 2014

N2 - Besides type I interferons (IFNs), type III IFNs, including IFN lambda 1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFN lambda 3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFN lambda were observed between patient groups, disease stages, or clinical parameters.

AB - Besides type I interferons (IFNs), type III IFNs, including IFN lambda 1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFN lambda 3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFN lambda were observed between patient groups, disease stages, or clinical parameters.

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EP - 556

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JF - Journal of Interferon and Cytokine Research

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