Endoscopic resection for residual oesophageal neoplasia after definitive chemoradiotherapy

Judith Honing; Arjun D. Koch; Peter D. Siersema; Manon Spaander

doi:10.1016/j.bpg.2024.101885

Endoscopic resection for residual oesophageal neoplasia after definitive chemoradiotherapy

Judith Honing, Arjun D. Koch, Peter D. Siersema, Manon Spaander^*

^*Corresponding author for this work

Gastroenterology & Hepatology

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Abstract

Definitive chemoradiation is the recommended treatment for locally advanced, irresectable oesophageal cancer and a valid alternative to neoadjuvant chemoradiotherapy (CRT) with surgery in oesophageal squamous cell cancer (OSCC) patients. In case of locoregional recurrence, salvage treatment can be considered in fit and resectable patients. Salvage surgery is a valid option but associated with significant morbidity. Therefore, for tumors confined to the mucosa or submucosal layers endoscopic resection is a good and less-invasive alternative. Over the last decade several case-series have demonstrated a high technical success rate of endoscopic treatment after definitive CRT. In this review we summarize the clinical outcomes and challenges of endoscopic treatment of early recurrence after definitive CRT in oesophageal cancer.

Original language	English
Article number	101885
Journal	Best Practice and Research: Clinical Gastroenterology
Volume	68
Early online date	31 Jan 2024
DOIs	https://doi.org/10.1016/j.bpg.2024.101885
Publication status	Published - Feb 2024

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abstract = "Definitive chemoradiation is the recommended treatment for locally advanced, irresectable oesophageal cancer and a valid alternative to neoadjuvant chemoradiotherapy (CRT) with surgery in oesophageal squamous cell cancer (OSCC) patients. In case of locoregional recurrence, salvage treatment can be considered in fit and resectable patients. Salvage surgery is a valid option but associated with significant morbidity. Therefore, for tumors confined to the mucosa or submucosal layers endoscopic resection is a good and less-invasive alternative. Over the last decade several case-series have demonstrated a high technical success rate of endoscopic treatment after definitive CRT. In this review we summarize the clinical outcomes and challenges of endoscopic treatment of early recurrence after definitive CRT in oesophageal cancer.",

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Endoscopic resection for residual oesophageal neoplasia after definitive chemoradiotherapy

Abstract

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