Endothelial protein C activation in meningococcal sepsis

Jan Hazelzet, E de Kleyn, Ronald Groot

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

27 Citations (Scopus)


To the Editor:
In the August 9 issue, Faust et al. reported that the level of endothelial expression of thrombomodulin and the endothelial protein C receptor was lower in patients with meningococcal sepsis than in control subjects. This finding has clinical implications, because it suggests that therapy with activated protein C2 may be superior to treatment with unactivated protein C3 in patients with sepsis. [...]
Original languageEnglish
Pages (from-to)1776-1777
Number of pages2
JournalNew England Journal of Medicine
Issue number24
Publication statusPublished - 13 Dec 2001


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