Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

Liangbin Zhou; Jietao Xu; Andrea Schwab; Wenxue Tong; Jiankun Xu; Lizhen Zheng; Ye Li; Zhuo Li; Shunxiang Xu; Ziyi Chen; Li Zou; Xin Zhao; Gerjo J.V.M. van Osch; Chunyi Wen; Ling Qin

doi:10.1016/j.bioactmat.2023.03.008

Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

Liangbin Zhou, Jietao Xu, Andrea Schwab, Wenxue Tong, Jiankun Xu, Lizhen Zheng, Ye Li, Zhuo Li, Shunxiang Xu, Ziyi Chen, Li Zou, Xin Zhao, Gerjo J.V.M. van Osch^*, Chunyi Wen^*, Ling Qin^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture, mosaicplasty, autologous chondrocyte implantation (ACI), and matrix-induced ACI (MACI). However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short-term durability. It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native AC. Acellular regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments. A deeper understanding of the mechanism of endogenous cartilage healing is furthering the (bio)design and application of these scaffolds. Currently, the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells (ESPCs) presents an evolving improvement for cartilage repair. This review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage regeneration. Then several intrinsic hurdles for regenerative biomaterials-based AC repair are discussed. The recent advances in novel (bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs (e.g. adhesion, migration, proliferation, differentiation, matrix production, and remodeling) for cartilage repair are summarized. Finally, this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultimate clinical translation.

Original language	English
Pages (from-to)	490-512
Number of pages	23
Journal	Bioactive Materials
Volume	26
DOIs	https://doi.org/10.1016/j.bioactmat.2023.03.008
Publication status	Published - Aug 2023

Bibliographical note

Funding Information:
This work was supported by the Areas of Excellence Scheme from University Grant Council of Hong Kong (AoE/M-402/20), the AO Foundation, Switzerland (AO-OCD Consortium TA1711481), the Theme-based Research Scheme from University Grant Council of Hong Kong (T13-402/17-N) as well as the Mainland-Hong Kong Joint Funding Scheme of Innovation and Technology Fund: ITF MHKJFS (MHP/011/20). Besides, thank Dr. Kevin Ki-Wai Ho and Dr. Yang Liu for providing valuable clinical theranostics photographs of human knee cartilage defects.

Publisher Copyright:
© 2023 The Authors

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Engineered biochemical cues of regenerative biomaterials to enhance endogenous stemprogenitor cells (ESPCs)-mediated articular cartilage repairFinal published version, 23.2 MBLicence: CC BY

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Zhou, L., Xu, J., Schwab, A., Tong, W., Xu, J., Zheng, L., Li, Y., Li, Z., Xu, S., Chen, Z., Zou, L., Zhao, X., van Osch, G. J. V. M., Wen, C., & Qin, L. (2023). Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair. Bioactive Materials, 26, 490-512. https://doi.org/10.1016/j.bioactmat.2023.03.008

@article{0af3b8aa8c25463a91369ca5de586306,

title = "Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair",

abstract = "As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture, mosaicplasty, autologous chondrocyte implantation (ACI), and matrix-induced ACI (MACI). However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short-term durability. It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native AC. Acellular regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments. A deeper understanding of the mechanism of endogenous cartilage healing is furthering the (bio)design and application of these scaffolds. Currently, the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells (ESPCs) presents an evolving improvement for cartilage repair. This review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage regeneration. Then several intrinsic hurdles for regenerative biomaterials-based AC repair are discussed. The recent advances in novel (bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs (e.g. adhesion, migration, proliferation, differentiation, matrix production, and remodeling) for cartilage repair are summarized. Finally, this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultimate clinical translation.",

author = "Liangbin Zhou and Jietao Xu and Andrea Schwab and Wenxue Tong and Jiankun Xu and Lizhen Zheng and Ye Li and Zhuo Li and Shunxiang Xu and Ziyi Chen and Li Zou and Xin Zhao and {van Osch}, {Gerjo J.V.M.} and Chunyi Wen and Ling Qin",

note = "Funding Information: This work was supported by the Areas of Excellence Scheme from University Grant Council of Hong Kong (AoE/M-402/20), the AO Foundation, Switzerland (AO-OCD Consortium TA1711481), the Theme-based Research Scheme from University Grant Council of Hong Kong (T13-402/17-N) as well as the Mainland-Hong Kong Joint Funding Scheme of Innovation and Technology Fund: ITF MHKJFS (MHP/011/20). Besides, thank Dr. Kevin Ki-Wai Ho and Dr. Yang Liu for providing valuable clinical theranostics photographs of human knee cartilage defects. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = aug,

doi = "10.1016/j.bioactmat.2023.03.008",

language = "English",

volume = "26",

pages = "490--512",

journal = "Bioactive Materials",

issn = "2452-199X",

publisher = "KeAi Publishing Communications Ltd.",

}

Zhou, L, Xu, J , Schwab, A, Tong, W, Xu, J, Zheng, L, Li, Y, Li, Z, Xu, S, Chen, Z, Zou, L, Zhao, X, van Osch, GJVM, Wen, C & Qin, L 2023, 'Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair', Bioactive Materials, vol. 26, pp. 490-512. https://doi.org/10.1016/j.bioactmat.2023.03.008

TY - JOUR

T1 - Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

AU - Zhou, Liangbin

AU - Xu, Jietao

AU - Schwab, Andrea

AU - Tong, Wenxue

AU - Xu, Jiankun

AU - Zheng, Lizhen

AU - Li, Ye

AU - Li, Zhuo

AU - Xu, Shunxiang

AU - Chen, Ziyi

AU - Zou, Li

AU - Zhao, Xin

AU - van Osch, Gerjo J.V.M.

AU - Wen, Chunyi

AU - Qin, Ling

N1 - Funding Information: This work was supported by the Areas of Excellence Scheme from University Grant Council of Hong Kong (AoE/M-402/20), the AO Foundation, Switzerland (AO-OCD Consortium TA1711481), the Theme-based Research Scheme from University Grant Council of Hong Kong (T13-402/17-N) as well as the Mainland-Hong Kong Joint Funding Scheme of Innovation and Technology Fund: ITF MHKJFS (MHP/011/20). Besides, thank Dr. Kevin Ki-Wai Ho and Dr. Yang Liu for providing valuable clinical theranostics photographs of human knee cartilage defects. Publisher Copyright: © 2023 The Authors

PY - 2023/8

Y1 - 2023/8

N2 - As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture, mosaicplasty, autologous chondrocyte implantation (ACI), and matrix-induced ACI (MACI). However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short-term durability. It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native AC. Acellular regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments. A deeper understanding of the mechanism of endogenous cartilage healing is furthering the (bio)design and application of these scaffolds. Currently, the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells (ESPCs) presents an evolving improvement for cartilage repair. This review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage regeneration. Then several intrinsic hurdles for regenerative biomaterials-based AC repair are discussed. The recent advances in novel (bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs (e.g. adhesion, migration, proliferation, differentiation, matrix production, and remodeling) for cartilage repair are summarized. Finally, this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultimate clinical translation.

AB - As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture, mosaicplasty, autologous chondrocyte implantation (ACI), and matrix-induced ACI (MACI). However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short-term durability. It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native AC. Acellular regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments. A deeper understanding of the mechanism of endogenous cartilage healing is furthering the (bio)design and application of these scaffolds. Currently, the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells (ESPCs) presents an evolving improvement for cartilage repair. This review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage regeneration. Then several intrinsic hurdles for regenerative biomaterials-based AC repair are discussed. The recent advances in novel (bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs (e.g. adhesion, migration, proliferation, differentiation, matrix production, and remodeling) for cartilage repair are summarized. Finally, this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultimate clinical translation.

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U2 - 10.1016/j.bioactmat.2023.03.008

DO - 10.1016/j.bioactmat.2023.03.008

M3 - Review article

C2 - 37304336

AN - SCOPUS:85154038232

SN - 2452-199X

VL - 26

SP - 490

EP - 512

JO - Bioactive Materials

JF - Bioactive Materials

ER -

Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

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