Enhancers and silencers: an integrated and simple model for their function

Petros Kolovos, Tobias Knoch, Frank Grosveld, PR Cook, A Papantonis

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82 Citations (Scopus)
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Abstract

Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').
Original languageUndefined/Unknown
JournalEpigenetics & Chromatin
Volume5
DOIs
Publication statusPublished - 2012

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