ENIGMA-Sleep: Challenges, opportunities, and the road map

Masoud Tahmasian*, André Aleman, Ole A. Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna Bright, Michael W.L. Chee, Daphne Chylinski, Wei Cheng, Michele Deantoni, Martin Dresler, Simon B. Eickhoff, Claudia R. Eickhoff, Torbjørn Elvsåshagen, Jianfeng Feng, Jessica C. Foster-Dingley, Habib Ganjgahi, Hans J. GrabeNynke A. Groenewold, Tiffany C. Ho, Seung Bong Hong, Josselin Houenou, Benson Irungu, Neda Jahanshad, Habibolah Khazaie, Hosung Kim, Ekaterina Koshmanova, Desi Kocevska, Peter Kochunov, Oti Lakbila-Kamal, Jeanne Leerssen, Meng Li, Annemarie I. Luik, Vincenzo Muto, Justinas Narbutas, Gustav Nilsonne, Victoria S. O’Callaghan, Alexander Olsen, Ricardo S. Osorio, Sara Poletti, Govinda Poudel, Joyce E. Reesen, Liesbeth Reneman, Mathilde Reyt, Dieter Riemann, Ivana Rosenzweig, Masoumeh Rostampour, Amin Saberi, Julian Schiel, Christina Schmidt, Anouk Schrantee, Emma Sciberras, Tim J. Silk, Kang Sim, Hanne Smevik, Jair C. Soares, Kai Spiegelhalder, Dan J. Stein, Puneet Talwar, Sandra Tamm, Giana l. Teresi, Sofie L. Valk, Eus Van Someren, Gilles Vandewalle, Maxime Van Egroo, Henry Völzke, Martin Walter, Rick Wassing, Frederik D. Weber, Antoine Weihs, Lars Tjelta Westlye, Margaret J. Wright, Mon Ju Wu, Nathalia Zak, Mojtaba Zarei

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

10 Citations (Scopus)

Abstract

Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.

Original languageEnglish
Article numbere13347
JournalJournal of Sleep Research
Volume30
Issue number6
Early online date28 Apr 2021
DOIs
Publication statusPublished - Dec 2021

Bibliographical note

Funding Information:
GN was supported by Riksbankens Jubileumsfond (grant no. P15‐0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS‐FNRS Belgium). The research included here was funded by Wallonia‐Brussels Federation (ARC ‐ 09/14‐03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO‐CR‐2010‐06E), FNRS‐Belgium (FRS‐FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Liège (ULiège), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC‐Starting Grant ‐ GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13‐1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care.

Funding Information:
GN was supported by Riksbankens Jubileumsfond (grant no. P15-0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS-FNRS Belgium). The research included here was funded by Wallonia-Brussels Federation (ARC - 09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO-CR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li?ge (ULi?ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC-Starting Grant - GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13-1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care.

Publisher Copyright:
© 2021 European Sleep Research Society

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