Environmental exposures to cadmium and lead as potential causes of eye diseases

Moein Ebrahimi, Maryam Ebrahimi, Joëlle E. Vergroesen, Michael Aschner, Mika Sillanpää

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)
31 Downloads (Pure)

Abstract

Humans are exposed to cadmium and lead in various regions of the world daily due to industrial development and climate change. Increasing numbers of preclinical and clinical studies indicate that heavy metals, such as cadmium and lead, play a role in the pathogenesis of eye diseases. Excessive exposure to heavy metals such as cadmium and lead can increase the risk of impaired vision. Therefore, it is essential to better characterize the role of these non-essential metals in disease etiology and progression. This article discusses the potential role of cadmium and lead in the development of age-related eye diseases, including age-related macular degeneration, cataracts, and glaucoma. Furthermore, we discuss how cadmium and lead affect ocular cells and provide an overview of putative pathological mechanisms associated with their propensity to damage the eye.

Original languageEnglish
Article number127358
JournalJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Volume82
DOIs
Publication statusPublished - 1 Mar 2024

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