EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma

E Franceschi, R Stupp, Martin van den Bent, C van Herpen, FL Donadey, T Gorlia, M Hegi, B Lhermitte, LC Strauss, A Allgeier, D Lacombe, AA Brandes

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Abstract

The treatment of patients with recurrent glioblastoma remains a major oncologic problem, with median survival after progression of 79 months. To determine the maximum tolerated dose and dose-limiting toxicity (DLT), the combination of dasatinib and cyclonexyl-chloroethyl-nitrosourea (CCNU) was investigated in this setting. The study was designed as multicenter, randomized phase II trial, preceded by a lead-in safety phase. The safety component reported here, which also investigated pharmacokinetics and preliminary clinical activity, required expansion and is therefore considered a phase I part to establish a recommended dosing regimen of the combination of CCNU (90110 mg/m(2)) and dasatinib (100200 mg daily). Overall, 28 patients were screened, and 26 patients were enrolled. Five dose levels were explored. DLTs, mainly myelosuppression, occurred in 10 patients. Grade 3 or 4 neutropenia was recorded in 7 patients (26.9) and thrombocytopenia in 11 patients (42.3). No significant effect of CCNU coadministration on dasatinib pharmacokinetics was found. Median progression-free survival (PFS) was 1.35 months (95 confidence interval: 1.21.4) and 6-month PFS was 7.7. In this phase I study of recurrent glioblastoma patients, the combination of CCNU and dasatinib showed significant hematological toxicities and led to suboptimal exposure to both agents.
Original languageUndefined/Unknown
Pages (from-to)1503-1510
Number of pages8
JournalNeuro-Oncology
Volume14
Issue number12
DOIs
Publication statusPublished - 2012

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