TY - JOUR
T1 - Eosinophilia and granulocytic dysplasia terminating in acute-myeloid leukaemia after 24 years
AU - Doorduijn, J. K.
AU - Van Lom, K.
AU - Löwenberg, B.
PY - 1996/12
Y1 - 1996/12
N2 - Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplatic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.
AB - Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplatic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.
UR - https://www.scopus.com/pages/publications/0029859226
U2 - 10.1046/j.1365-2141.1996.d01-1931.x
DO - 10.1046/j.1365-2141.1996.d01-1931.x
M3 - Article
C2 - 8943897
AN - SCOPUS:0029859226
SN - 0007-1048
VL - 95
SP - 531
EP - 534
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -