Epidemic spread of recombinant noroviruses with four capsid types in Hungary

Gábor Reuter*, Harry Vennema, Marion Koopmans, György Szücs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)


Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe.

Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary.

Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing.

Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%).

Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalJournal of Clinical Virology
Issue number1
Publication statusPublished - Jan 2006
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by grants from the Hungarian Medical Research Council (ETT 118/2000), the Hungarian Scientific Research Fund (OTKA, F048433), and the projects of “Food-borne Viruses in Europe” (FBVE, QLK1-CT-1999-00594), “Enteric Virus Emergence, New Tools” (EVENT, SP22-CT-2004-502571) and “Prevention of emerging (food-borne) enteric viral infections: diagnosis, viability testing, networking and epidemiology (DIVINE-NET, 2003213) funded by the European Union.


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