Epidemic spread of recombinant noroviruses with four capsid types in Hungary

Gábor Reuter; Harry Vennema; Marion Koopmans; György Szücs

doi:10.1016/j.jcv.2005.07.012

Epidemic spread of recombinant noroviruses with four capsid types in Hungary

Gábor Reuter^*
, Harry Vennema
, Marion Koopmans
, György Szücs

^*Corresponding author for this work

National Institute of Public Health and the Environment
ÁNTSZ Baranya County Institute of State Public Health Service

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe.

Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary.

Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing.

Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%).

Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.

Original language	English
Pages (from-to)	84-88
Number of pages	5
Journal	Journal of Clinical Virology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.jcv.2005.07.012
Publication status	Published - Jan 2006
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by grants from the Hungarian Medical Research Council (ETT 118/2000), the Hungarian Scientific Research Fund (OTKA, F048433), and the projects of “Food-borne Viruses in Europe” (FBVE, QLK1-CT-1999-00594), “Enteric Virus Emergence, New Tools” (EVENT, SP22-CT-2004-502571) and “Prevention of emerging (food-borne) enteric viral infections: diagnosis, viability testing, networking and epidemiology (DIVINE-NET, 2003213) funded by the European Union.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.jcv.2005.07.012

Cite this

@article{7b3e36a2dad04af2bc63276f6207d2be,

title = "Epidemic spread of recombinant noroviruses with four capsid types in Hungary",

abstract = "Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing {"}GGIIb/Hilversum polymerase{"} (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4\%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43\%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28\%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19\%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5\%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.",

author = "G{\'a}bor Reuter and Harry Vennema and Marion Koopmans and Gy{\"o}rgy Sz{\"u}cs",

note = "Funding Information: This study was supported in part by grants from the Hungarian Medical Research Council (ETT 118/2000), the Hungarian Scientific Research Fund (OTKA, F048433), and the projects of “Food-borne Viruses in Europe” (FBVE, QLK1-CT-1999-00594), “Enteric Virus Emergence, New Tools” (EVENT, SP22-CT-2004-502571) and “Prevention of emerging (food-borne) enteric viral infections: diagnosis, viability testing, networking and epidemiology (DIVINE-NET, 2003213) funded by the European Union.",

year = "2006",

month = jan,

doi = "10.1016/j.jcv.2005.07.012",

language = "English",

volume = "35",

pages = "84--88",

journal = "Journal of Clinical Virology",

issn = "1386-6532",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Epidemic spread of recombinant noroviruses with four capsid types in Hungary

AU - Reuter, Gábor

AU - Vennema, Harry

AU - Koopmans, Marion

AU - Szücs, György

N1 - Funding Information: This study was supported in part by grants from the Hungarian Medical Research Council (ETT 118/2000), the Hungarian Scientific Research Fund (OTKA, F048433), and the projects of “Food-borne Viruses in Europe” (FBVE, QLK1-CT-1999-00594), “Enteric Virus Emergence, New Tools” (EVENT, SP22-CT-2004-502571) and “Prevention of emerging (food-borne) enteric viral infections: diagnosis, viability testing, networking and epidemiology (DIVINE-NET, 2003213) funded by the European Union.

PY - 2006/1

Y1 - 2006/1

N2 - Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.

AB - Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.

UR - https://www.scopus.com/pages/publications/29644443621

U2 - 10.1016/j.jcv.2005.07.012

DO - 10.1016/j.jcv.2005.07.012

M3 - Article

C2 - 16242995

AN - SCOPUS:29644443621

SN - 1386-6532

VL - 35

SP - 84

EP - 88

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

IS - 1

ER -

Epidemic spread of recombinant noroviruses with four capsid types in Hungary

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this