Epidemiological studies on adipokines and osteoarthritis

Erlangga Yusuf*, Margreet Kloppenburg

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

2 Citations (Scopus)


Obesity is an important risk factor for not only knee, but also hand, osteoarthritis. Since hand joints do not experience mechanical force like weight-bearing joints such as the knee, other explanations on how obesity leads to osteoarthritis are needed. One of the possible explanations is adipokines, metabolic factors secreted by fat tissue. This paper reviews epidemiological studies on the role of three adipokines (leptin, adiponectin and resistin) in osteoarthritis, and briefly discusses the evidence from experimental research and future agenda on this topic.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalInternational Journal of Clinical Rheumatology
Issue number3
Publication statusPublished - Jun 2013
Externally publishedYes


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