Epidemiology of Charcot-Marie-Tooth Disease in the Population of Belgrade, Serbia

J (J.) Mladenovic, VM Rasic, MK Markovic, S Romac, S Todorovic, VR Stojanovic, DK Tepavcevic, Bert Hofman, T Pekmezovic

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Abstract

Background: The aim of this study was to determine prevalence and 15-year survival in Charcot-Marie-Tooth disease (CMT). Methods: The study covers the period from 1 January 1988 to 31 December 2007 in the territory of Belgrade. Data on a number of CMT-affected persons and their basic demographic characteristics as well as data on the disease were collected from medical records. Data on the course and outcome of the disease were obtained through direct contact with patients, their families and their physicians. Results: We registered 161 patients with CMT in the population of Belgrade. The most frequent type was CMT1. The crude prevalence of CMT disease in the Belgrade population on 31 December 2007 was 9.7/100,000 for all subtypes, 7.1/100,000 for CMT1, and 2.3/100,000 for CMT2. Gender-specific prevalence was 11.2/100,000 for males and 8.3/100,000 for females. The highest age-specific prevalence was registered in the oldest age group (75+ years; 19.1/100,000), and the lowest one in patients aged 5-14 years (5.0/100,000). The cumulative probability of 15-year survival for CMT patients in Belgrade was 85.6 +/- 7.8% (44.9 +/- 31.8% for males and 98.2 +/- 1.8% for females). Conclusions: The prevalence of CMT found in Belgrade is similar to the prevalence registered in Southern European countries. Copyright (C) 2011 S. Karger AG, Basel
Original languageUndefined/Unknown
Pages (from-to)177-182
Number of pages6
JournalNeuroepidemiology
Volume36
Issue number3
DOIs
Publication statusPublished - 2011

Research programs

  • EMC NIHES-01-64-01

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