Epidemiology of Extracutaneous Melanoma in the Netherlands

ER Koomen, Esther Vries, LC van Kempen, Alexander Akkooi, HJ Guchelaar, Woutera Louwman, Tamar Nijsten, Jan Willem Coebergh

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Abstract

Background: Reliable population-based incidence and survival data on extracutaneous melanoma (ECM) are sparse. Methods: Incidence data (1989-2006) from the Netherlands Cancer Registry were combined with vital status on January 1, 2008. Age-adjusted annual incidence rates were calculated by direct standardization, and the estimated annual percentage change was estimated to detect changing trends in incidence. Additionally, we carried out cohort-based relative survival analysis. Results: Ocular melanomas were the most common ECM subsite with European standardized incidence rates (ESR) of 10.7 and 8.2 per 1,000,000 person-years for males and females, respectively. In comparison, for cutaneous melanoma (CM), the ESRs for men and women were 122 and 155 per million person-years, respectively. No statistically significant trends in the incidence of ECM were detected, whereas an annual increase of 4.4% for men and 3.6% for women was detected in the incidence of CM. Relative survival for ECM was poor, but differed largely between anatomic subtypes ranging from a 5-year relative survival of 74% for ocular melanomas to 15% for certain subsites of mucosal melanomas. Conclusions: Of all ECM subsites, ocular melanomas had the highest incidence and the best survival. Mucosal melanomas were the second most frequent subsite of ECM. Five-year relative survival for all ECM subtypes was worse if compared with CM. No statistically significant trends in the incidence of (subsites of) ECM were determined. Impact: This study gives insight into the relative sizes of the different subgroups of ECM as well as an estimate of 5-year survival, which varies substantially by subsite. Cancer Epidemiol Biomarkers Prev; 19(6); 1453-9. (C) 2010 AACR.
Original languageUndefined/Unknown
Pages (from-to)1453-1459
Number of pages7
JournalCancer Epidemiology Biomarkers & Prevention
Volume19
Issue number6
DOIs
Publication statusPublished - 2010

Research programs

  • EMC MM-03-47-11
  • EMC MM-03-61-05-A
  • EMC NIHES-02-65-02

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