Epigenetic regulation and musculoskeletal injuries

Mary Jessica N. Laguette, Mathijs A.M. Suijkerbuijk, Alison V. September

Research output: Chapter/Conference proceedingChapterAcademic

Abstract

Musculoskeletal injuries have a considerable socio-economic impact and are increasing in prevalence. Previous work has identified several intrinsic and extrinsic risk factors contributing to injury susceptibility. Recent work has identified a role for epigenetics as a contributing mechanism to the susceptibility of musculoskeletal soft tissue injuries. The current chapter focuses on new development in the epigenetics arena towards understanding the risk of musculoskeletal soft tissue injuries. Using case-control association studies, differential DNA methylation and miRNA profiles were observed in the context of patellar tendinopathy, rotator cuff tendon tears, Achilles tendon injuries, and anterior cruciate ligament ruptures. Moreover, clinical and ethical implications of epigenetic research and testing remain a central theme and were discussed. The recent development in this field suggests that it is plausible that epigenetic modifications may modulate extracellular matrix proteins’ function and/or expression, thereby contributing to musculoskeletal soft tissue injuries.

Original languageEnglish
Title of host publicationEpigenetics of Exercise and Sports
Subtitle of host publicationConcepts, Methods, and Current Research
PublisherElsevier Inc.
Chapter11
Pages235-246
Number of pages12
ISBN (Electronic)9780128206829
DOIs
Publication statusPublished - 1 Jan 2021

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