Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

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Abstract

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent discoveries have highlighted an additional important role of dysregulated epigenetic mechanisms in the pathogenesis of the disease. In contrast to genetic changes, epigenetic modifications are frequently reversible, which provides opportunities for targeted treatment using specific inhibitors. In this review, we will provide overview of the current state of epigenetics and epigenetic therapy in AML and will describe perspectives on how to identify promising new approaches for epigenetic targeted treatment.
Original languageUndefined/Unknown
Pages (from-to)42-52
Number of pages11
JournalBlood
Volume127
Issue number1
DOIs
Publication statusPublished - 2016

Research programs

  • EMC MM-02-41-03

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