Abstract
New emerging evidence suggests that the role of epigenetic alterations in diabetes is a crucial intersection between genetic predisposition and environmental factors. Two of the most studied epigenetic marks, DNA methylation and histone modifications, were investigated in relation to type 2 diabetes and glycemic traits, including glucose, insulin, and insulin resistance. However, no consistent associations between epigenetic marks and diabetes have been found. The majority of studies have reported differential DNA methylation of candidate genes in relation to diabetes and glycemic indices, but no overlap has been found between the differentially methylated CpGs sites in epigenome-wide association studies. Although there have been some promising results in the field of diabetes and epigenetics, challenges related to study design, harmonized methodology of assessment, tissue heterogeneity, and others remain. Diabetes epigenetics may hold the future potential of generating new information that can be used to predict high-risk patients and disease prevention.
| Original language | English |
|---|---|
| Title of host publication | Epigenetics in Human Disease |
| Publisher | Elsevier Inc. |
| Pages | 457-488 |
| Number of pages | 32 |
| ISBN (Electronic) | 9780128122150 |
| ISBN (Print) | 9780128123294 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc. All rights reserved.
