Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis

Willem S. Eikelboom; Nikki Janssen; Lize C. Jiskoot; Esther van den Berg; Ardi Roelofs; Roy P. C. Kessels

doi:10.1016/j.neubiorev.2018.06.015

Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis

Willem S. Eikelboom, Nikki Janssen^*, Lize C. Jiskoot, Esther van den Berg, Ardi Roelofs, Roy P. C. Kessels

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.

Method: Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.

Results: Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], p

Conclusions: Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.

Original language	English
Pages (from-to)	243-254
Number of pages	12
Journal	Neuroscience and Biobehavioral Reviews
Volume	92
DOIs	https://doi.org/10.1016/j.neubiorev.2018.06.015
Publication status	Published - Sept 2018

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http://hdl.handle.net/1765/109019

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title = "Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis",

abstract = "Objective: The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.Method: Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.Results: Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], pConclusions: Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.",

author = "Eikelboom, {Willem S.} and Nikki Janssen and Jiskoot, {Lize C.} and {van den Berg}, Esther and Ardi Roelofs and Kessels, {Roy P. C.}",

year = "2018",

month = sep,

doi = "10.1016/j.neubiorev.2018.06.015",

language = "English",

volume = "92",

pages = "243--254",

journal = "Neuroscience and Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Episodic and working memory function in Primary Progressive Aphasia

T2 - A meta-analysis

AU - Eikelboom, Willem S.

AU - Janssen, Nikki

AU - Jiskoot, Lize C.

AU - van den Berg, Esther

AU - Roelofs, Ardi

AU - Kessels, Roy P. C.

PY - 2018/9

Y1 - 2018/9

N2 - Objective: The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.Method: Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.Results: Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], pConclusions: Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.

AB - Objective: The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.Method: Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.Results: Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], pConclusions: Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.

U2 - 10.1016/j.neubiorev.2018.06.015

DO - 10.1016/j.neubiorev.2018.06.015

M3 - Article

C2 - 29928907

SN - 0149-7634

VL - 92

SP - 243

EP - 254

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis

Abstract

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