ESHO benchmarks for computational modeling and optimization in hyperthermia therapy

Margarethus M. Paulides*, Dario B. Rodrigues, Gennaro G. Bellizzi, Kemal Sumser, Sergio Curto, Esra Neufeld, Hazael Montanaro, H. Petra Kok, Hana Dobsicek Trefna

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
55 Downloads (Pure)


Background: The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment planning, optimization and decision making, as well as real-time treatment guidance. Materials and methods: The same computational methods deployed in HTP are also used for in silico studies. These are of great relevance for the development of new HT devices and treatment approaches. To aid this work, 3 D patient models have been recently developed and made available for the HT community. Unfortunately, there is no consensus regarding tissue properties, simulation settings, and benchmark applicators, which significantly influence the clinical relevance of computational outcomes. Results and discussion: Herein, we propose a comprehensive set of applicator benchmarks, efficacy and safety optimization algorithms, simulation settings and clinical parameters, to establish benchmarks for method comparison and code verification, to provide guidance, and in view of the 2021 ESHO Grand Challenge (Details on the ESHO grand challenge on HTP will be provided at Conclusion: We aim to establish guidelines to promote standardization within the hyperthermia community such that novel approaches can quickly prove their benefit as quickly as possible in clinically relevant simulation scenarios. This paper is primarily focused on radiofrequency and microwave hyperthermia but, since 3 D simulation studies on heating with ultrasound are now a reality, guidance as well as a benchmark for ultrasound-based hyperthermia are also included.

Original languageEnglish
Pages (from-to)1425-1442
Number of pages18
JournalInternational Journal of Hyperthermia
Issue number1
Publication statusPublished - 28 Sept 2021

Bibliographical note

Funding Information:
This work was supported by COST Action MyWave CA17115 ?European network for advancing Electromagnetic hyperthermic medical technologies?, Dutch Cancer Society proejct 11368 and the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845645.

Publisher Copyright:
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.


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