Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Yunpeng Ji; Pengfei Li; Yueqi Jia; Xiaohua Wang; Qinyue Zheng; Maikel P. Peppelenbosch; Zhongren Ma; Qiuwei Pan

doi:10.1016/j.onehlt.2021.100350

Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Yunpeng Ji, Pengfei Li, Yueqi Jia, Xiaohua Wang, Qinyue Zheng, Maikel P. Peppelenbosch, Zhongren Ma^*, Qiuwei Pan^*

^*Corresponding author for this work

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.

Original language	English
Article number	100350
Journal	One Health
Volume	13
DOIs	https://doi.org/10.1016/j.onehlt.2021.100350
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
We thank the Changjiang Scholars and Innovative Research Team in University grant (No. IRT_17R88 ) from the Ministry of Education of the People's Republic of China to Z. Ma, and the Netherlands Organization for Scientific Research (NWO) for funding a VIDI grant ( 91719300 ) to Q.P.

Publisher Copyright:
© 2021

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10.1016/j.onehlt.2021.100350

1-s2.0-S2352771421001403-mainFinal published version, 1.76 MBLicence: CC BY-NC-ND

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title = "Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries",

abstract = "Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.",

author = "Yunpeng Ji and Pengfei Li and Yueqi Jia and Xiaohua Wang and Qinyue Zheng and Peppelenbosch, {Maikel P.} and Zhongren Ma and Qiuwei Pan",

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AU - Ji, Yunpeng

AU - Li, Pengfei

AU - Jia, Yueqi

AU - Wang, Xiaohua

AU - Zheng, Qinyue

AU - Peppelenbosch, Maikel P.

AU - Ma, Zhongren

AU - Pan, Qiuwei

N1 - Funding Information: We thank the Changjiang Scholars and Innovative Research Team in University grant (No. IRT_17R88 ) from the Ministry of Education of the People's Republic of China to Z. Ma, and the Netherlands Organization for Scientific Research (NWO) for funding a VIDI grant ( 91719300 ) to Q.P. Publisher Copyright: © 2021

PY - 2021/12

Y1 - 2021/12

N2 - Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.

AB - Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.

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DO - 10.1016/j.onehlt.2021.100350

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SN - 2352-7714

VL - 13

JO - One Health

JF - One Health

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ER -

Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Abstract

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