Ethnic differences in childhood right and left cardiac structure and function assessed by cardiac magnetic resonance imaging

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Abstract

Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life. We examined the ethnic differences in cardiac structure and function in children using cardiac magnetic resonance imaging in a European migrant population, and whether any difference was explained by early life factors. We used a prospective population-based cohort study among 2317 children in Rotterdam, the Netherlands. We compared children from Dutch (73%), Cape Verdean (3.5%), Dutch Antillean (3.3%), Moroccan (6.1%), Surinamese-Creoles (3.9%), Surinamese-Hindustani (3.4%), and Turkish (6.4%) background. Main outcomes were cMRI-measured cardiac structures and function. Cardiac outcomes were standardized on body surface area. Cape Verdean, Surinamese-Hindustani, and Turkish children had smaller right ventricular end-diastolic volume and left ventricular end-diastolic volume relative to their body size than Dutch children (p < 0.05). These results were not fully explained by fetal and childhood factors. Right ventricular ejection fraction and left ventricular ejection fraction did not differ between ethnicities after adjustment for fetal and childhood factors. Conclusion: Right ventricular end-diastolic volume and left ventricular end-diastolic volume differ between ethnic subgroups in childhood, without affecting ejection fraction. Follow-up studies are needed to investigate whether these differences lead to ethnic differences in cardiac disease in adulthood.What is Known:• Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life.• The prevalence of cardiovascular disease differs between ethnic groups.What is New:• We examined ethnic differences in left and right cardiac structure and function in children using cMRI.• Right and left cardiac dimensions differ between ethnic groups in childhood and are only partly explained by fetal and childhood factors.

Original languageEnglish
Pages (from-to)1257-1266
Number of pages10
JournalEuropean Journal of Pediatrics
Volume180
Issue number4
DOIs
Publication statusPublished - Apr 2021

Bibliographical note

Funding Information:
The Generation R Study is made possible by financial support from the Erasmus University Medical Centre, Rotterdam; the Erasmus University Rotterdam; and the Netherlands Organization for Health Research and Development. Romy Gaillard received a grant from the Dutch Heart Foundation (grant number 2017T013). Vincent Jaddoe received a Consolidator Grant from the European Research Council (ERC-2014-CoG-648916). Acknowledgments

Funding Information:
We gratefully acknowledge the contribution of the participating children, their mothers, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam; and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam.

Publisher Copyright:
© 2020, The Author(s).

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