ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

J. H. von der Thüsen; D. W. Dumoulin; A. P.W.M. Maat; J. Wolf; A. H. Sadeghi; J. G.J.V. Aerts; R. Cornelissen

doi:10.1016/j.lungcan.2021.04.015

ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

J. H. von der Thüsen^*, D. W. Dumoulin, A. P.W.M. Maat, J. Wolf, A. H. Sadeghi, J. G.J.V. Aerts, R. Cornelissen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Introduction: NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered. Methods: We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS. Results: On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma. Conclusions: This entity represents a novel subtype of non-small cell lung cancer, which we would like to term ‘ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma’.

Original language	English
Pages (from-to)	72-75
Number of pages	4
Journal	Lung Cancer
Volume	156
DOIs	https://doi.org/10.1016/j.lungcan.2021.04.015
Publication status	Published - Jun 2021

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1-s2.0-S0169500221001562-mainFinal published version, 4.82 MBLicence: CC BY

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@article{1fd831b09559415f9ebef77d1bd5296f,

title = "ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype",

abstract = "Introduction: NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered. Methods: We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS. Results: On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma. Conclusions: This entity represents a novel subtype of non-small cell lung cancer, which we would like to term {\textquoteleft}ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma{\textquoteright}.",

author = "{von der Th{\"u}sen}, {J. H.} and Dumoulin, {D. W.} and Maat, {A. P.W.M.} and J. Wolf and Sadeghi, {A. H.} and Aerts, {J. G.J.V.} and R. Cornelissen",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = jun,

doi = "10.1016/j.lungcan.2021.04.015",

language = "English",

volume = "156",

pages = "72--75",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma

T2 - A novel bronchial salivary gland-type non-small cell lung cancer subtype

AU - von der Thüsen, J. H.

AU - Dumoulin, D. W.

AU - Maat, A. P.W.M.

AU - Wolf, J.

AU - Sadeghi, A. H.

AU - Aerts, J. G.J.V.

AU - Cornelissen, R.

PY - 2021/6

Y1 - 2021/6

N2 - Introduction: NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered. Methods: We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS. Results: On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma. Conclusions: This entity represents a novel subtype of non-small cell lung cancer, which we would like to term ‘ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma’.

AB - Introduction: NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered. Methods: We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS. Results: On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma. Conclusions: This entity represents a novel subtype of non-small cell lung cancer, which we would like to term ‘ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma’.

UR - http://www.scopus.com/inward/record.url?scp=85105258903&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2021.04.015

DO - 10.1016/j.lungcan.2021.04.015

M3 - Article

C2 - 33895680

AN - SCOPUS:85105258903

VL - 156

SP - 72

EP - 75

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

ER -

ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

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