Evaluating the molecular and genetic mechanisms underlying gut motility disorders

Atchariya Chanpong, Maria M. Alves, Elena Bonora, Roberto De Giorgio, Nikhil Thapar*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


Introduction: Gastrointestinal (GI) motility disorders comprise a wide range of different diseases affecting the structural or functional integrity of the GI neuromusculature. Their clinical presentation and burden of disease depends on the predominant location and extent of gut involvement as well as the component of the gut neuromusculature affected. Areas covered: A comprehensive literature review was conducted using the PubMed and Medline databases to identify articles related to GI motility and functional disorders, published between 2016 and 2023. In this article, we highlight the current knowledge of molecular and genetic mechanisms underlying GI dysmotility, including disorders of gut–brain interaction, which involve both GI motor and sensory disturbance. Expert opinion: Although the pathophysiology and molecular mechanisms underlying many such disorders remain unclear, recent advances in the assessment of intestinal tissue samples, genetic testing with the application of ‘omics’ technologies and the use of animal models will provide better insights into disease pathogenesis as well as opportunities to improve therapy.

Original languageEnglish
Pages (from-to)1301-1312
Number of pages12
JournalExpert Review of Gastroenterology and Hepatology
Issue number12
Publication statusE-pub ahead of print - 20 Dec 2023

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