Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

Carolien Sandt, Joost Kreijtz, Guus Rimmelzwaan

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143 Citations (Scopus)
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Abstract

The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
Original languageUndefined/Unknown
Pages (from-to)1438-1476
Number of pages39
JournalViruses-Basel
Volume4
Issue number9
DOIs
Publication statusPublished - 2012

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