Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: Fine-tuning by hormonal regulation and mRNA stability

Claudia Bruedigam, Marijke Koedam, H Chiba, Marco Eijken, Hans van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

The expression, regulation and functional significance of multiple peroxisome proliferator-activated receptor gamma transcript variants in bone were studied. PPARG transcripts giving rise to PPARg-1 protein were expressed in human osteoblasts, whereas PPARG-2 transcript and protein remained virtually absent. PPARG expression underwent homologous regulation, was upregulated during differentiation and directly induced by the osteogenic hormone dexamethasone, suggesting a role for PPARg-1 in osteogenesis. Differences between the stabilities of PPARG-1, -3 and -4 were observed. We hypothesize that cell-specific expression patterns of multiple PPARG transcript variants encoding for the same protein but differing in mRNA stabilities enable a fine-tuning of PPARG action, which eventually supports a well-adjusted signal transduction between the cell and its environment. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)1618-1624
Number of pages7
JournalFEBS Letters. Journal for the Rapid Publication of Short Reports in Biochemistry .....
Volume582
Issue number11
DOIs
Publication statusPublished - 2008

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