Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh

S Nahar; KMK Kibria; ME Hossain; J Sultana; SA Sarker; L Engstrand; PK Bardhan; M Rahman; Hubert Endtz

doi:10.1007/s10096-008-0699-8

Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh

S Nahar, KMK Kibria, ME Hossain, J Sultana, SA Sarker, L Engstrand, PK Bardhan, M Rahman, Hubert Endtz

Medical Microbiology & Infectious Diseases

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.

Original language	Undefined/Unknown
Pages (from-to)	767-773
Number of pages	7
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	28
Issue number	7
DOIs	https://doi.org/10.1007/s10096-008-0699-8
Publication status	Published - 2009

Research programs

EMC MM-04-28-01

Access to Document

10.1007/s10096-008-0699-8

http://hdl.handle.net/1765/15749

Cite this

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title = "Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh",

abstract = "Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.",

author = "S Nahar and KMK Kibria and ME Hossain and J Sultana and SA Sarker and L Engstrand and PK Bardhan and M Rahman and Hubert Endtz",

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T1 - Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh

AU - Nahar, S

AU - Kibria, KMK

AU - Hossain, ME

AU - Sultana, J

AU - Sarker, SA

AU - Engstrand, L

AU - Bardhan, PK

AU - Rahman, M

AU - Endtz, Hubert

PY - 2009

Y1 - 2009

N2 - Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.

AB - Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.

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JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

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