Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh

S Nahar, KMK Kibria, ME Hossain, J Sultana, SA Sarker, L Engstrand, PK Bardhan, M Rahman, Hubert Endtz

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26 Citations (Scopus)


Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.
Original languageUndefined/Unknown
Pages (from-to)767-773
Number of pages7
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Issue number7
Publication statusPublished - 2009

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