Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS): large-scale data sharing initiative

Cynthia S Hofman*, Jennifer E Lutomski, Han Boter, Bianca M Buurman, Anton JM De Craen, Rogier Donders, Marcel GM Olde Rikkert, Peter Makai, René JF Melis, TOPICS-MDS research consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
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Abstract

Background
Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey—Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital).

Methods
Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril’s ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression.

Results
In the complete sample and when stratified by study setting TOPICS-CEP and Cantril’s ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup.

Conclusion
This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.
Original languageUndefined/Unknown
Article numbere0173081
JournalPLoS ONE
Volume13
Issue number4
DOIs
Publication statusPublished - 2018
Externally publishedYes

Bibliographical note

Funding:
This work was supported by The Dutch
National Care for the Elderly Programme,
coordinated and sponsored by ZonMw,
organization for health research and development,
The Netherlands [Grant number: 60-61900-98-
302]. The funder had no role in the study design,
data collection and analysis, decision to publish, or
preparation of the manuscript.

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