TY - JOUR
T1 - Expanding the Scope of Microvascular Inflammation
T2 - Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts
AU - Varol, Hilal
AU - Wagenmakers, Anne
AU - Hoeft, Konrad
AU - Callemeyn, Jasper
AU - Bodewes, Roos
AU - Bramer, Wichor
AU - Stubbs, Andrew
AU - Kramann, Rafael
AU - Naesens, Maarten
AU - Clahsen-Van Groningen, Marian C.
N1 - Publisher Copyright:
Copyright © 2025 Varol, Wagenmakers, Hoeft, Callemeyn, Bodewes, Bramer, Stubbs, Kramann, Naesens and Clahsen-Van Groningen.
PY - 2025/1/6
Y1 - 2025/1/6
N2 - Microvascular inflammation (MVI) in kidney transplant biopsies is mainly associated with antibody-mediated rejection (AMR), sparking debate within the Banff Classification of Renal Allograft Pathology regarding its exclusivity. This study reviewed the literature on MVI in T cell-mediated rejection (TCMR) and analyzed MVI in our transplant population. We searched English publications in MEDLINE, Embase, Web of Science, Cochrane, and Google Scholar until June 2024, focusing on glomerulitis (g), peritubular capillaritis (ptc), or MVI in kidney transplant biopsies classified as TCMR. Additionally, we examined g, ptc, and MVI in 69 patients with AMR, TCMR, and no rejection. Our search yielded 541 citations, with 10 studies included, covering 810 TCMR and 156 AMR biopsies. The studies showed g, ptc, and MVI were present in TCMR but were less prevalent and severe than in AMR. In our cohort, AMR had significantly higher g, ptc, and MVI scores compared to aTCMR and ATN, however, aTCMR also displayed MVI. These findings confirm that MVI occurs in aTCMR and should not be exclusively linked to AMR. These findings highlight the need to further explore MVI’s significance in TCMR and investigate the inflammatory composition. This could refine the Banff Classification, improving Classification accuracy of kidney transplant pathology assessments.
AB - Microvascular inflammation (MVI) in kidney transplant biopsies is mainly associated with antibody-mediated rejection (AMR), sparking debate within the Banff Classification of Renal Allograft Pathology regarding its exclusivity. This study reviewed the literature on MVI in T cell-mediated rejection (TCMR) and analyzed MVI in our transplant population. We searched English publications in MEDLINE, Embase, Web of Science, Cochrane, and Google Scholar until June 2024, focusing on glomerulitis (g), peritubular capillaritis (ptc), or MVI in kidney transplant biopsies classified as TCMR. Additionally, we examined g, ptc, and MVI in 69 patients with AMR, TCMR, and no rejection. Our search yielded 541 citations, with 10 studies included, covering 810 TCMR and 156 AMR biopsies. The studies showed g, ptc, and MVI were present in TCMR but were less prevalent and severe than in AMR. In our cohort, AMR had significantly higher g, ptc, and MVI scores compared to aTCMR and ATN, however, aTCMR also displayed MVI. These findings confirm that MVI occurs in aTCMR and should not be exclusively linked to AMR. These findings highlight the need to further explore MVI’s significance in TCMR and investigate the inflammatory composition. This could refine the Banff Classification, improving Classification accuracy of kidney transplant pathology assessments.
UR - https://www.scopus.com/pages/publications/85215272773
U2 - 10.3389/ti.2024.13464
DO - 10.3389/ti.2024.13464
M3 - Article
C2 - 39834692
AN - SCOPUS:85215272773
SN - 0934-0874
VL - 37
JO - Transplant International
JF - Transplant International
M1 - 13464
ER -