Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review

Nikita H.Z. Clasen; M. E.Madeleine van der Perk; Sebastian J.C.M.M. Neggers; Annelies M.E. Bos; Marry M. van den Heuvel-Eibrink

doi:10.3390/cancers15071946

Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review

Nikita H.Z. Clasen^*
, M. E.Madeleine van der Perk
, Sebastian J.C.M.M. Neggers
, Annelies M.E. Bos
, Marry M. van den Heuvel-Eibrink

^*Corresponding author for this work

Internal Medicine

Princess Máxima Center for Pediatric Oncology
Vrije Universiteit Amsterdam
Utrecht University

Research output: Contribution to journal › Review article › Academic › peer-review

12 Citations (Web of Science)

58 Downloads (Pure)

Abstract

Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children’s health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling.

Original language	English
Article number	1946
Journal	Cancers
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/cancers15071946
Publication status	Published - Apr 2023

Bibliographical note

Funding Information:
M.E.M. van der Perk is supported by funding from the Princess Máxima Center Foundation, Twinning in Research and Education to Improve Survival in Childhood Solid Tumors in Lithuania (TREL) (funded by European Union’s Horizon 2020 research and innovation programme H2020-EU.4.b) and Stichting Kinderoncologisch Centrum Rotterdam (sKOCR).

Publisher Copyright:
© 2023 by the authors.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at DiagnosisFinal published version, 439 KBLicence: CC BY

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Clasen, N. H. Z., van der Perk, M. E. M., Neggers, S. J. C. M. M., Bos, A. M. E., & van den Heuvel-Eibrink, M. M. (2023). Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review. Cancers, 15(7), Article 1946. https://doi.org/10.3390/cancers15071946

@article{3aac703f6faf4dcc84f96eff299d6d1a,

title = "Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review",

abstract = "Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children{\textquoteright}s health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling.",

author = "Clasen, \{Nikita H.Z.\} and \{van der Perk\}, \{M. E.Madeleine\} and Neggers, \{Sebastian J.C.M.M.\} and Bos, \{Annelies M.E.\} and \{van den Heuvel-Eibrink\}, \{Marry M.\}",

note = "Funding Information: M.E.M. van der Perk is supported by funding from the Princess M{\'a}xima Center Foundation, Twinning in Research and Education to Improve Survival in Childhood Solid Tumors in Lithuania (TREL) (funded by European Union{\textquoteright}s Horizon 2020 research and innovation programme H2020-EU.4.b) and Stichting Kinderoncologisch Centrum Rotterdam (sKOCR). Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = apr,

doi = "10.3390/cancers15071946",

language = "English",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review. / Clasen, Nikita H.Z.; van der Perk, M. E.Madeleine; Neggers, Sebastian J.C.M.M. et al.
In: Cancers, Vol. 15, No. 7, 1946, 04.2023.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis

T2 - A Systematic Review

AU - Clasen, Nikita H.Z.

AU - van der Perk, M. E.Madeleine

AU - Neggers, Sebastian J.C.M.M.

AU - Bos, Annelies M.E.

AU - van den Heuvel-Eibrink, Marry M.

N1 - Funding Information: M.E.M. van der Perk is supported by funding from the Princess Máxima Center Foundation, Twinning in Research and Education to Improve Survival in Childhood Solid Tumors in Lithuania (TREL) (funded by European Union’s Horizon 2020 research and innovation programme H2020-EU.4.b) and Stichting Kinderoncologisch Centrum Rotterdam (sKOCR). Publisher Copyright: © 2023 by the authors.

PY - 2023/4

Y1 - 2023/4

N2 - Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children’s health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling.

AB - Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children’s health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling.

UR - https://www.scopus.com/pages/publications/85152470546

U2 - 10.3390/cancers15071946

DO - 10.3390/cancers15071946

M3 - Review article

C2 - 37046607

AN - SCOPUS:85152470546

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 7

M1 - 1946

ER -

Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review

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