Exploiting DNA repair defects for novel cancer therapies

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Abstract

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
Original languageUndefined/Unknown
Pages (from-to)2145-2148
Number of pages4
JournalMolecular Biology of the Cell
Volume27
Issue number14
DOIs
Publication statusPublished - 2016

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