Exploiting DNA repair defects for novel cancer therapies

Dik van Gent; Roland Kanaar

doi:10.1091/mbc.E15-10-0698

Exploiting DNA repair defects for novel cancer therapies

Dik van Gent, Roland Kanaar

Molecular Genetics

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

18 Downloads (Pure)

Abstract

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.

Original language	Undefined/Unknown
Pages (from-to)	2145-2148
Number of pages	4
Journal	Molecular Biology of the Cell
Volume	27
Issue number	14
DOIs	https://doi.org/10.1091/mbc.E15-10-0698
Publication status	Published - 2016

Research programs

EMC MGC-01-12-03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1091/mbc.E15-10-0698

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Cite this

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